PMID: 6814263Nov 1, 1982

Antifolliculogenic action of progesterone despite hypersecretion of FSH in monkeys

The American Journal of Physiology
A L Goodman, G D Hodgen

Abstract

To learn how progesterone (P) inhibits follicle growth during the luteal phase, we determined whether P will inhibit follicle growth when follicle-stimulating hormone (FSH) is secreted in large amounts, namely, after luteectomy (CLX) in monkeys with only one ovary. Second, a functional role for 17 alpha-hydroxyprogesterone (17OHP) was examined as a common mediator of the inhibition of folliculogenesis by the dominant follicle and corpus luteum. To accomplish the first goal, nine chronically hemiovarectomized monkeys were lutectomized chronically hemiovariectomized monkeys were luteectomized at midluteal phase. In five monkeys that received no steroid, the next preovulatory luteinizing hormone (LH) surge occurred 14.0 +/- 0.8 days (mean +/- SE) after CLX. In contrast, the next LH surge was delayed in four monkeys implanted for 10 days with Silastic capsules containing P and occurred 25.0 +/- 2.7 days after CLX, i.e., 14.8 +/- 2.7 days after the capsule removal. In both groups, FSH levels increased markedly after CLX to a comparable degree and duration; yet, only a single follicle ovulated in each monkey. To examine a potential inhibitory role for 17OHP, monkeys with two ovaries were luteectomized and received 1) no steroid, 2) 1...Continue Reading

References

Feb 1, 1979·The Journal of Clinical Endocrinology and Metabolism·A L Goodman, G D Hodgen
Dec 1, 1971·American Journal of Obstetrics and Gynecology·I H ThorneycroftR M Nakamura
Jul 1, 1971·The Journal of Clinical Endocrinology and Metabolism·G E AbrahamW D Odell
Sep 1, 1969·The Journal of Clinical Endocrinology and Metabolism·C A StrottM B Lipsett
Jul 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G S diZerega, G D Hodgen
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·R L Stouffer, G D Hodgen
Jan 1, 1981·Endocrine Reviews·G S diZerega, G D Hodgen

Citations

Mar 1, 1986·Journal of Dairy Science·M F Smith

Related Concepts

Castration
Structure of Corpus Luteum of Ovary
Estradiol, (16 alpha,17 beta)-Isomer
Follicle Stimulating Hormone
Atretic Follicle
Luteozyman
Luteal Phase
Macaca fascicularis
Progesterone, (9 beta,10 alpha)-Isomer

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