Antifouling activity of the sponge metabolite agelasine D and synthesised analogs on Balanus improvisus

Biofouling
Martin SjögrenLars Bohlin

Abstract

This study reports a screening study for antifouling (AF) activity of the natural compound agelasine D isolated from marine sponges of the genus Agelas and 20 synthesised analogs of agelasines and agelasimines. Agelasine D, together with two of the analogs, ie AV1003A and AKB695, displayed a strong inhibitory effect on settlement of Balanus improvisus cypris larvae. Agelasine D had an EC50 value of 0.11 microM while the two analogs AV1033A and AKB695 had EC50 values of 0.23 and 0.3 microM, respectively. None of these three compounds affected larval mortality as was the case with several of the analogs tested. Moreover, the effect of AV1033A and AKB695 was reversible. When cyprids after 24 h exposure to the compounds were transferred to fresh seawater, the settlement frequency compared with the controls was completely recovered. The properties of the agelasine D analogs AV1003A and AKB695 make them highly attractive candidates as AF agents in future marine coatings.

References

Apr 1, 1989·Canadian Journal of Physiology and Pharmacology·R Fathi-AfsharC E Cass
May 19, 1998·Journal of Natural Products·X FuM Kelly-Borges
Oct 24, 1998·Journal of Natural Products·X ShenM T Hamann
Oct 24, 1998·Journal of Natural Products·T Iwagawa van Soest RWM
Oct 9, 1999·Journal of Natural Products·C EderS Sudarsono
Aug 26, 2000·Journal of Experimental Marine Biology and Ecology·K M BerntssonP Gatenholm
Jul 12, 2002·Applied Microbiology and Biotechnology·P ProkschR Ebel
Aug 6, 2002·Science·Martyn PoliakoffPaul T Anastas
Mar 29, 2003·Environmental Pollution·Kevin V ThomasMike Waldock
Nov 19, 2003·Biofouling·J Grant BurgessDavid R Adams
Mar 25, 2004·Natural Product Reports·John W BluntMichèle R Prinsep
Mar 27, 2004·Journal of Natural Products·Martin SjögrenLars Bohlin
Aug 31, 2004·Journal of Natural Products·Ulf GöranssonLars Bohlin
Mar 8, 2005·Organic & Biomolecular Chemistry·Anne Kristin BakkestuenAnders Vik
Oct 26, 2005·Chembiochem : a European Journal of Chemical Biology·Gabriele M KönigDaniela Müller
Mar 28, 2006·Journal of Natural Products·Anders VikLars Bohlin
Mar 24, 2007·Journal of Natural Products·Erika SvangårdUlf Göransson
Apr 20, 2007·Bioorganic & Medicinal Chemistry·Anders VikLise-Lotte Gundersen
Aug 24, 2007·Marine Biotechnology·Sofia OrtleppPeter Proksch

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Citations

Apr 9, 2009·Biofouling·J Fredrik LindgrenPer R Jonsson
Dec 25, 2010·Biofouling·Daniela BlihogheAngelo Fontana
Jan 26, 2010·Marine Drugs·Marina Gordaliza
Oct 29, 2013·Purinergic Signalling·Wolfgang FischerMichael Schaefer
Dec 5, 2009·Biofouling·Pei-Yuan QianNobushino Fusetani
Jan 13, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anders VikLise-Lotte Gundersen
Jan 8, 2011·Archiv der Pharmazie·Heidi RoggenLise-Lotte Gundersen
Mar 10, 2015·Biotechnology Advances·Joana R Almeida, Vitor Vasconcelos
Nov 18, 2010·Natural Product Reports·Nobuhiro Fusetani
Dec 3, 2010·Natural Product Reports·Valerie J PaulKoty Sharp
May 1, 2021·Marine Drugs·Disha VarijakzhanChou-Min Chong
Jan 7, 2011·Journal of Natural Products·Fernanda R da SilvaAntonio Ferreira-Pereira

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