Antifouling zwitterionic hydrogel coating improves hemocompatibility of activated carbon hemoadsorbent

Journal of Colloid and Interface Science
Nana CaiLei Zhang

Abstract

Activated carbon has been widely used in hemoperfusion treatments. However, its performance has been significantly compromised by their poor hemocompatibility. In this work, we developed a novel antifouling adsorbent based on zwitterionic poly-carboxybetaine (PCB) hydrogel and powdered activated carbon (PAC) to improve hemocompatibility. We found this new adsorbent (PCB-PAC) was highly stable with negligible leakage of activated carbon debris. It could efficiently resist protein adsorption and avoid any hemolysis effect. The adsorption performance of PCB-PAC for methylene blue was not influenced in a single protein solution or even in 100% fetal bovine serum (FBS), in which pristine PAC lost 50% of its adsorption ability. The isotherms results showed that the adsorption process of PCB-PAC fitted the Langmuir isotherm well, indicating that the PAC particles were homogenously distributed in the PCB hydrogel matrix. Moreover, PCB-PAC could also adsorb bilirubin molecules bound to albumin in solution, while pristine PAC showed no discernible adsorption effect. Findings in this work hold great potential to significantly improve the performance and efficiency of current extracorporeal devices for removing toxins from blood directly.

Citations

Jul 19, 2018·Journal of Materials Science. Materials in Medicine·Lei ZhangHaishan Qi
Nov 15, 2018·Micromachines·Madeline SmallShih-Feng Chou
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yunhong LiuYugang Huang
Feb 6, 2021·Therapeutics and Clinical Risk Management·Zhi-Yong ZhangYi-Xin Zhao
May 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenhui ChenFu Liu
Jun 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Na GanHui Li
Jul 2, 2021·Journal of Colloid and Interface Science·Yujie ChenXiumei Mo
Dec 15, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Harpreet PangliAziz Ghahary
May 13, 2020·ACS Applied Materials & Interfaces·Qingsi LiLei Zhang
Feb 3, 2018·ACS Applied Materials & Interfaces·Jiamin ZhangLei Zhang
Jun 20, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Qingsi LiLei Zhang
Dec 20, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jiayin SongLei Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Francisco J RealFrancisco Casas
© 2022 Meta ULC. All rights reserved