Antifungal activities of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Fusarium spp

Medical Mycology
Tarcieli P VenturiniSydney Hartz Alves

Abstract

Herein, we describe the in vitro activity of a combination of the organoselenium compounds diphenyl diselenide and ebselen alone and in combination with amphotericin B, caspofungin, itraconazole, and voriconazole against 25 clinical isolates of Fusarium spp. For this analysis, we used the broth microdilution method based on the M38-A2 technique and checkerboard microdilution method. Diphenyl diselenide (MIC range = 4-32 μg/ml) and ebselen (MIC range = 2-8 μg/ml) showed in vitro activity against the isolates tested. The most effective combinations were (synergism rates): ebselen + amphotericin B (88%), ebselen + voriconazole (80%), diphenyl diselenide + amphotericin B (72%), and diphenyl diselenide + voriconazole (64%). Combination with caspofungin resulted in low rates of synergism: ebselen + caspofungin, 36%, and diphenyl diselenide + caspofungin, 28%; combination with itraconazole demonstrated indifferent interactions. Antagonistic effects were not observed for any of the combinations tested. Our findings suggest that the antifungal potential of diphenyl diselenide and ebselen deserves further investigation in in vivo experimental models, especially in combination with amphotericin B and voriconazole.

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Citations

Oct 5, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Thaís Felli KubiçaSydney Hartz Alves
Aug 4, 2016·Journal of Cellular Biochemistry·Gláubia SartoriCristina W Nogueira
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Jun 21, 2018·Medical Mycology·Vanice Rodrigues PoesterMelissa Orzechowski Xavier
Apr 8, 2020·Medical Microbiology and Immunology·Maral GharaghaniAli Zarei-Mahmoudabadi
Aug 28, 2020·Medical Mycology·Aryse Martins MeloMelissa Orzechowski Xavier
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Jan 1, 2019·European Journal of Medicinal Chemistry·Nishad Thamban ChandrikaSylvie Garneau-Tsodikova
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Apr 29, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Vanice Rodrigues PoesterMelissa Orzechowski Xavier
Jan 10, 2021·Medical Mycology·Jéssica Louise BenelliMelissa Orzechowski Xavier
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Oct 17, 2020·ChemMedChem·Nishad Thamban ChandrikaSylvie Garneau-Tsodikova
Oct 23, 2019·Journal of Medicinal Chemistry·Ana Carolina RuberteDaniel Plano

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