Antifungal activity against Cryptococcus neoformans strains and genotoxicity assessment in human leukocyte cells of Euphorbia tirucalli L

Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]
Luis F S de OliveiraMichel M Machado

Abstract

In the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L.) against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex preparation were effective against ten clinical strains of Cryptococcus neoformans in vitro (Latex and extract MIC range of 3.2 - > 411 μg/mL). Aiming the safe use in humans, the genotoxic effects of E. tirucalli were evaluated in human leukocytes cells. Our data show that both aqueous extract and latex preparation have no genotoxic effect in human leukocytes cells in vitro. Although the results cannot be extrapolated by itself for use in vivo, they suggest a good perspective for a th...Continue Reading

Citations

Nov 8, 2017·Letters in Applied Microbiology·A M FuentefriaS F de Andrade
Mar 10, 2017·Drug and Chemical Toxicology·Rosiane Soares SaturninoJúlio César Nepomuceno

❮ Previous
Next ❯

Datasets Mentioned

BETA
SMD
10127

Methods Mentioned

BETA
Assay

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Bioorganic & Medicinal Chemistry Letters
Chung-Kyu RyuAram Kim
Bioorganic & Medicinal Chemistry Letters
Chung-Kyu RyuAram Kim
Revista Do Instituto De Medicina Tropical De São Paulo
Thaísa Cristina SilvaMaria do Rosário Rodrigues Silva
© 2021 Meta ULC. All rights reserved