Antifungal activity and nail permeation of nail lacquer containing Piper regnellii (Miq.) C. CD. var. pallescens (C. DC.) Yunck (Piperaceae) leave extracts and derivatives.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Andrea M KoroishiBenedito Prado Dias Filho

Abstract

The dermatophytes are filamentous fungi that cause cutaneous fungal infections because they use keratin as a nutrient source. For this study the antidermatophyte activity of the extracts and derivates from leaves of Piper regnellii was analyzed. From the dichloromethane extract (EBD) neolignans such as eupomatenoid-3 and eupomatenoid-5 were obtained, and it was submitted to fractionation to remove the green residue, designated as the chloroform fraction (FF). Extracts, chloroform fraction and compounds were tested against Trichophyton rubrum ATCC 28189 to determine the minimum inhibitory concentration (MIC). The chloroform fraction was incorporated to nail lacquer that was analyzed by photoacoustic spectroscopy, in vitro assay and scanning electronic microscopy. For antifungal activity in solid medium the dichloromethane extract and chloroform fraction were used. The compounds eupomatenoid-3 and eupomatenoid-5 were less active than the dichloromethane extract against T. rubrum. EBD and FF showed moderate activity in hyphal growth inhibition in solid medium and EBD did not link to ergosterol. Nail lacquer containing the chloroform fraction showed good penetration through the nail as determined by photoacoustic spectroscopy. From...Continue Reading

References

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Citations

Sep 28, 2014·Fitoterapia·Ying WangLing-Yi Kong
Oct 1, 2015·Drug Delivery and Translational Research·Ronak S BhuptaniVandana B Patravale
Dec 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karine Zanoli BernuciDiógenes Aparício Garcia Cortez
Dec 3, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariele Caroline Marques Nogueira PuhlBenedito Prado Dias Filho
Dec 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karine Zanoli BernuciDiógenes Aparício Garcia Cortez

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Methods Mentioned

BETA
scanning electronic microscopy
column chromatography
Assay

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