Antifungal activity of a food-grade dilution-stable microemulsion against Aspergillus niger

Letters in Applied Microbiology
Hui ZhangX Zheng

Abstract

To study the antifungal activities of a prepared food-grade dilution-stable microemulsion against Aspergillus niger. Results from the antifungal activity on solid medium by agar dilution method showed that the microemulsion caused complete growth inhibition at 2000 ppm, and at 1000 ppm, showed 55% growth inhibition after 4 days of incubation and a delay of conidiation by 1 day compared with controls. Results from the antifungal activity in liquid medium by broth dilution method showed that the growth of A. niger was completely inhibited when a liquid medium containing 10(6) spores per ml was treated with 500 ppm of microemulsion, which was determined by minimum fungicidal concentration. Study of fungicidal kinetics showed that more than 99% of viable spores were killed within 15 min. These antifungal activities were confirmed by scanning electron microscopy, light microscopy and increased Ca(+2), K(+) and Mg(+2) leakages. The results suggest that the prepared microemulsions are effective antifungal systems with excellent growth inhibition and sporicidal activities, and indicate that their antifungal activity may be to the result of the disruption and dysfunction of A. niger cell walls and biological membranes. This study sugges...Continue Reading

References

Aug 17, 2000·Journal of Applied Microbiology·I S Al-AdhamP J Collier
Jan 22, 2003·Letters in Applied Microbiology·I S I Al-AdhamP J Collier
Mar 11, 2006·Critical Reviews in Food Science and Nutrition·John Flanagan, Harjinder Singh
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Citations

May 4, 2010·Applied Microbiology and Biotechnology·Hui ZhangLirong Shen
Jul 9, 2013·International Journal of Pharmaceutics·Ibrahim S I Al-AdhamPhillip J Collier
Jun 29, 2010·International Journal of Pharmaceutics·Hui ZhangXiaodong Zheng
Mar 8, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joshua A JackmanNam-Joon Cho
Jun 15, 2012·Journal of the Science of Food and Agriculture·Shi-Xiang XuXiao-Dong Zheng

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