Antifungal activity of Andrographis paniculata extracts and active principles against skin pathogenic fungal strains in vitro

Pharmaceutical Biology
Abubakar SuleBashar Bello S Dogarai

Abstract

Andrographis paniculata Nees. (Acanthaceae) is an annual herbaceous plant widely cultivated in southern Asia, China, and Europe. It is used in the treatment of skin infections in India, China, and Malaysia by folk medicine practitioners. Antifungal activity of the whole plant extracts and isolation of active principles from A. paniculata were investigated. Dichloromethane (DCM) and methanol (MEOH) extracts of A. paniculata whole plant were screened for their antifungal potential using broth microdilution method in vitro against seven pathogenic fungal species responsible for skin infections. Active principles were detected through bioguided assays and isolated using chromatography techniques. Structures of compounds were elucidated through spectroscopy techniques and comparisons were made with previously reported data for similar compounds. DCM extract revealed lowest minimum inhibitory concentration (MIC) value (100 μg/mL) against Microsporum canis, Candida albicans, and Candida tropicalis, whereas MEOH extract revealed lowest MIC (150 µg/mL) against C. tropicalis and Aspergillus niger. DCM extract showed lowest minimum fungicidal concentration (MFC) value (250 µg/mL) against M. canis, C. albicans, C. tropicalis and A. niger, ...Continue Reading

References

Jan 19, 2000·Drug Discovery Today·J M Fostel, P A Lartey
Nov 25, 2003·Fitoterapia·Prajjal K SinghaS Dey
Aug 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·Mirentxu I IruretagoyenaAlexis M Kalergis
Jun 21, 2005·Journal of Ethnopharmacology·J L Ríos, M C Recio
Feb 8, 2006·Chemical & Pharmaceutical Bulletin·Sirivan AthikomkulchaiSomsak Ruchirawat
Oct 7, 2006·The Medical Journal of Australia·Linda C TapsellKaren E Inge
Dec 7, 2007·Journal of Ethnopharmacology·Ramar Perumal SamySavarimuthu Ignacimuthu
Jun 12, 2008·Phytotherapy Research : PTR·Madamanchi GeethangiliYew-Min Tzeng
Nov 13, 2008·Journal of Asian Natural Products Research·Kai-Lan ZhouFeng Qiu
Apr 12, 2011·Journal of Medicinal Food·Rodrigo Luiz FabriElita Scio
Jun 1, 1997·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·D D CáceresG K Wikman

❮ Previous
Next ❯

Citations

Aug 25, 2016·Scientific Reports·Chin-Kai TsengJin-Ching Lee
Oct 11, 2017·Pharmacognosy Reviews·Sameh SolimanAyman M Noreddin
Jan 1, 2014·TheScientificWorldJournal·Md Sanower HossainK M Hafizur Rahman
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nabil M Abdel-HamidDaniah Muneam Hamid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.