Antifungal activity of Annona coriacea Mart. ethanol extracts against the aetiological agents of cryptococcosis

Natural Product Research
Adriana Araújo de Almeida-ApolonioMarilene Rodrigues Chang

Abstract

Cryptococcosis is an opportunistic disease with a worldwide distribution. This disease is caused by fungi of the genus Cryptococcus, and its treatment is limited to several antifungals. In this study, the antifungal, cytotoxic and mutagenic properties of ethanol extracts from the bark and leaves of Annona coriacea were evaluated against the standard Cryptococcus species and clinical yeast specimens. Both extracts of A. coriacea showed inhibitory activity of 1.5 mg/mL for all of the yeasts tested. The number of viable cells at the lowest tested concentration was 0.187 mg/mL. The extracts that were tested showed inhibitory activity and reduced the fungal growth of the Cryptococcus gattii species and Cryptococcus neoformans species complexes, suggesting that this plant may be an effective alternative treatment for cryptococcosis.

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Citations

Jun 30, 2019·Natural Product Research·Alfred Ngenge TamfuFarzana Shaheen
Jan 24, 2021·Chemico-biological Interactions·Giovanna Nogueira da Silva Avelino Oliveira RochaJackson Roberto Guedes da Silva Almeida

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