Antifungal activity of antimicrobial-impregnated devices

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
R O DarouicheE M Kojic

Abstract

The in-vitro and in-vivo efficacy against Candida albicans and Candida krusei of devices impregnated with chlorhexidine and chloroxylenol was examined. The impregnated devices produced large zones of inhibition against both organisms (mean size, 39 mm and 38 mm, respectively). In a rabbit model in which segments of silicone catheters were placed percutaneously, non-impregnated devices were twice as likely as impregnated devices to become colonised with either C. albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008).

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Citations

Oct 9, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ShiY M Zhao
Aug 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P SchnitzlerJürgen Reichling
Nov 29, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M D Mansouri, R O Darouiche
Oct 7, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·E VerraedtJ A Martens
Dec 16, 2011·Trends in Microbiology·Fernanda L PaganelliHelen L Leavis
Apr 11, 2017·Chemistry, an Asian Journal·Annika KottmannUdo Kragl
Jul 9, 2010·The Journal of Craniofacial Surgery·Marcelo Coelho GoiatoFellippo Ramos Verri
Feb 16, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Mohammad JalalSuriya Rehman

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