Antifungal Activity of Crude Extract from the Rhizome and Root of Smilacina japonica A. Gray

Evidence-based Complementary and Alternative Medicine : ECAM
Wei LiuShengzheng Wang

Abstract

This study aimed to investigate the antifungal activity of hydroalcoholic extract from Smilacina japonicaA. Gray (SJA) against different fungi. The minimum inhibitory concentration (MIC) for SJA was determined by the broth microdilution method. The antifungal effects of SJA against Candida albicans were further confirmed by cell growth test and time-kill curve test. The effects of SJA on the fungal morphology and ultrastructure were also evaluated. SJA has a broad-spectrum antifungal activity. The MICs of SJA against different fungi, including fluconazole-sensitive and -resistant Candida albicans, other Candida species, and Cryptococcus neoformans, ranged from 208 μg/ml to 1665 μg/ml. Furthermore, SJA displayed fungicidal activity against varied fungi and obviously inhibited the hyphal growth of fungi. The mechanism study revealed that the antifungal activity of SJA might be associated with its effect on the cell morphology and ultrastructure.

References

Aug 14, 2003·Phytotherapy Research : PTR·Anna VollekováJaroslav Tóth
Jun 13, 2006·Steroids·Ying ZhangChong-Ren Yang
Jun 21, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Sônia Pereira LeiteEdeltrudes de Oliveira Lima
May 1, 2007·The Journal of Antimicrobial Chemotherapy·Marie-Thérèse BaixenchEric Dannaoui
Jan 27, 2009·Phytotherapy Research : PTR·Atiya FatimaSuman P S Khanuja
Oct 30, 2009·Cellular Microbiology·Frederic DalleBernhard Hube
Feb 23, 2011·Chemistry & Biology·Terry RoemerGerald F Bills
Dec 14, 2011·Expert Review of Anti-infective Therapy·Ilse D JacobsenBernhard Hube
Apr 3, 2012·Fitoterapia·Xia LiuLin Qi
May 15, 2012·Science·Gordon D BrownStuart M Levitz
May 23, 2012·Current Opinion in Microbiology·Neil A R Gow, Bernhard Hube
Jun 6, 2014·ACS Medicinal Chemistry Letters·Shengzheng WangChunquan Sheng
Jun 25, 2014·Emerging Infectious Diseases·Dounia BitarFrançoise Dromer
Jul 25, 2014·PloS One·Wei LiuYuan Ying Jiang
Mar 31, 2015·Science·David W Denning, Michael J Bromley
Jul 4, 2015·Journal of Molecular Microbiology and Biotechnology·Xiaodong JiangXiaoping Yang
Jan 8, 2016·Infectious Disease Clinics of North America·Snigdha VallabhaneniTom Chiller
Jun 9, 2016·Trends in Pharmacological Sciences·Mark G Moloney
Nov 7, 2016·Infectious Disease Clinics of North America·Geehan Suleyman, George J Alangaden
Dec 17, 2016·Emerging Infectious Diseases·Sara StrolloD Rebecca Prevots
Mar 18, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lulu ZhangYuan-Ying Jiang
Mar 28, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C BiswasV Sintchenko
Mar 1, 2018·Frontiers in Medicine·Mafalda Cavalheiro, Miguel Cacho Teixeira
Mar 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuwen CuiHaifeng Tang
Apr 6, 2018·Natural Product Research·Tatiana M Souza-MoreiraRosemeire C L R Pietro
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Longfei YangTonghui Ma
Feb 19, 2019·Chemical Biology & Drug Design·Sima Sadat SeyedjavadiMehdi Razzaghi-Abyaneh

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Methods Mentioned

BETA
Assay
light microscopy
flow cytometry

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