Antifungal activity of extracts and prenylated coumarins isolated from Baccharis darwinii Hook & Arn. (Asteraceae).

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Rita R KurdelasMonica L Freile

Abstract

The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 microg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 microg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 microg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.

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Citations

Jan 15, 2016·Chemistry & Biodiversity·Francinete Ramos CamposLeticia Bonancio Cerqueira
Nov 22, 2014·Archiv der Pharmazie·Monica OlivellaRicardo D Enriz
Jul 8, 2016·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Carlos F Medina-LópezEma C Rosas-Burgos
Jun 15, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriela Lemos de Azevedo MaiaJosé Maria Barbosa-Filho
Jun 14, 2018·Frontiers in Microbiology·Nilce M Martinez-RossiAntonio Rossi
Oct 25, 2016·Mycopathologia·Graciliana LopesLígia Salgueiro
Nov 13, 2021·International Journal of Dermatology·Marwan OsmanMonzer Hamze

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Methods Mentioned

BETA
NMR

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