Abstract
The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 microg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 microg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 microg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
References
Feb 1, 1987·Planta medica·H Soicke, E Leng-Peschlow
Jan 1, 1996·Natural Toxins·B B JarvisC S Barros
Jan 1, 1996·Dermatologic Clinics·I Weitzman, A A Padhye
Jan 8, 1998·Journal of Ethnopharmacology·E MongelliG Ciccia
Mar 17, 1999·Journal of Natural Products·G A WächterB N Timmermann
Apr 25, 2000·Journal of Agricultural and Food Chemistry·R D EnrizM Gordaliza
May 23, 2000·Phytochemistry·B JiménezM Grande
Oct 5, 2001·Journal of Ethnopharmacology·G E FeresinS A Zacchino
Nov 28, 2002·Phytochemistry·Diego A CifuenteCarlos E Tonn
Jul 24, 2003·Life Sciences·Irene ParejoCarles Codina
Oct 3, 2003·Journal of Ethnopharmacology·Gabriela Egly FeresinGuillermo Schmeda-Hirschmann
Nov 1, 2003·The Lancet Infectious Diseases·Nina Singh
Oct 28, 2004·Journal of Ethnopharmacology·Alejandro TapiaGuillermo Schmeda-Hirschmann
Jun 21, 2005·Journal of Ethnopharmacology·J L Ríos, M C Recio
Oct 6, 2005·Journal of Ethnopharmacology·M J AbadP Bermejo
Oct 15, 2005·Phytochemical Analysis : PCA·Cláudia A Simões-PiresKurt Hostettmann
Jan 2, 2008·Bioorganic & Medicinal Chemistry·Zhongze MaDavid Y W Lee
May 9, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Glauco MoralesLuis A Loyola
Sep 3, 2008·Journal of Ethnopharmacology·Maria G L BrandãoRoberto L M Monte-Mór
Oct 8, 2009·Journal of Ethnopharmacology·Diogo A dos SantosNara L M Quintão
Citations
Mar 31, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Zhiqiang GeFei Liao
Jan 15, 2016·Chemistry & Biodiversity·Francinete Ramos CamposLeticia Bonancio Cerqueira
Nov 22, 2014·Archiv der Pharmazie·Monica OlivellaRicardo D Enriz
Jul 8, 2016·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Carlos F Medina-LópezEma C Rosas-Burgos
Jun 15, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriela Lemos de Azevedo MaiaJosé Maria Barbosa-Filho
Jun 14, 2018·Frontiers in Microbiology·Nilce M Martinez-RossiAntonio Rossi
Oct 25, 2016·Mycopathologia·Graciliana LopesLígia Salgueiro
Jan 11, 2020·Journal of Ethnopharmacology·Silvana Lorena CarrizoMaría Inés Isla
Nov 13, 2021·International Journal of Dermatology·Marwan OsmanMonzer Hamze