Antifungal activity of extracts of some plants used in Brazilian traditional medicine against the pathogenic fungus Paracoccidioides brasiliensis

Pharmaceutical Biology
Susana JohannMaria Aparecida de Resende

Abstract

Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis Almeida (Onygenales) that requires 1-2 years of treatment. In the absence of drug therapy, the disease is usually fatal, highlighting the need for the identification of safer, novel, and more effective antifungal compounds. With this need in mind, several plants employed in Brazilian traditional medicine were assayed on P. brasiliensis and murine macrophages. Extracts were prepared from 10 plant species: Inga spp. Mill. (Leguminosae), Schinus terebinthifolius Raddi (Anacardiaceae), Punica granatum L. (Punicaceae), Alternanthera brasiliana Kuntze (Amaranthaceae), Piper regnellii CDC. (Piperaceae), P. abutiloides Kunth (Piperaceae), Herissantia crispa L. Briz. (Malvaceae), Rubus urticaefolius Poir (Rosaceae), Rumex acetosa L. (Polygonaceae), and Baccharis dracunculifolia DC. (Asteraceae). Hexane fractions from hydroalcoholic extracts of Piper regnellii and Baccharis dracunculifolia were the most active against the fungus, displaying minimum inhibitory concentration (MIC) values of 7.8 microg/mL and 7.8-30 mug/mL, respectively. Additionally, neither of the extracts exhibited any apparent cytotoxic effects on murine macrophages ...Continue Reading

References

Sep 1, 1989·Antimicrobial Agents and Chemotherapy·G San-BlasR Apitz-Castro
Jul 5, 1996·Journal of Ethnopharmacology·M J MartínezA Jauregui
May 1, 1999·The Journal of Antimicrobial Chemotherapy·O LortholaryB Dupont
Jan 20, 2000·Antimicrobial Agents and Chemotherapy·J OnishiM B Kurtz
Feb 27, 2001·Fitoterapia·D PrashanthA Amit
Feb 6, 2002·Trends in Microbiology·M Ines Borges-WalmsleyAdrian R Walmsley
Sep 10, 2002·Revista Do Instituto De Medicina Tropical De São Paulo·Carlos da Silva LacazMarilena dos Anjos Martins
Sep 24, 2002·Cadernos de saúde pública·Ziadir Francisco CoutinhoBodo Wanke
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Fabíola Barbiéri HoletzBenedito Prado Dias Filho
Dec 31, 2003·Journal of Ethnopharmacology·G Coelho de SouzaE Elisabetsky
Jul 21, 2004·Journal of Ethnopharmacology·Supayang VoravuthikunchaiThanomjit Supawita
Dec 28, 2004·Journal of Ethnopharmacology·Gracilene SchmourloSônia S Costa
Aug 15, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Aparecida Shikanai-YasudaMaria Luiza Moretti
Feb 6, 2007·Acta Biomaterialia·Karla SotoL E Murr
Jan 26, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Roman PaduchJan Fiedurek
Dec 1, 1994·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·V L MoraesS S Costa

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Citations

Jan 25, 2013·Journal of Clinical Microbiology·A C A de Paula e SilvaM J S Mendes-Giannini
Dec 2, 2011·Annual Review of Food Science and Technology·Suzanne D Johanningsmeier, G Keith Harris
Sep 19, 2015·Journal of Ethnopharmacology·Andrea VasasJudit Hohmann
Dec 5, 2015·Frontiers in Microbiology·Haroldo C de OliveiraMaria J S Mendes-Giannini
Feb 14, 2015·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Lidia Y TayJanaina H Jorge
Nov 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Laura CariddiLiliana Sabini
Apr 9, 2014·Natural Product Research·Marcela Isis MoraisLuciana Alves Rodrigues dos Santos Lima
May 28, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Graziela Teixeira de OliveiraLuciana Alves Rodrigues dos Santos Lima
Jan 11, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Luciana Alves Rodrigues dos Santos LimaMaria Amélia Diamantino Boaventura
Jul 28, 2018·Journal of Applied Microbiology·G MendesS Johann
Jun 27, 2018·Medical Mycology·Nívea Pereira de SáSusana Johann
Sep 7, 2017·Anais Da Academia Brasileira De Ciências·Maria E A PintoLuciana A R S Lima
Aug 28, 2019·Antimicrobial Agents and Chemotherapy·Ana Carolina Alves de Paula E SilvaMaria J S Mendes-Giannini
Nov 17, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Adriele Dandara Levorato VincheRinaldo Poncio Mendes
Aug 4, 2019·International Journal of Biological Macromolecules·Ananda Marques de GodoiRosa Elisa Carvalho Linhares
Sep 9, 2021·Clinical Microbiology Reviews·Oyelola AdegboyeClaire Loiseau
Sep 22, 2021·Inflammopharmacology·Rogério MarcheteThiago Antônio Moretti Andrade

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