Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans

Future Microbiology
Mônica Yonashiro MarcelinoAna Marisa Fusco-Almeida

Abstract

This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Fluconazole-loaded NRL membrane was obtained by casting method. The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.

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Citations

Jan 10, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Natan Roberto de BarrosAna Maria Queiros Norberto
Feb 12, 2020·Future Microbiology·Kaila P Medina-AlarcónAna M Fusco-Almeida
May 9, 2019·Applied Microbiology and Biotechnology·Bruna Cambraia GarmsRondinelli Donizetti Herculano
Nov 7, 2020·Future Microbiology·Thainá V da SilvaRondinelli D Herculano
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nayrim Brizuela GuerraRondinelli Donizetti Herculano
Aug 22, 2021·International Journal of Biological Macromolecules·Jean Lucas TanakaNatan Roberto de Barros

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