Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jianjun LuoMeiying Hu

Abstract

This study investigated the antifungal activity and potential antifungal mechanism(s) of isoliquiritin against P. litchi Chen, one of the main litchi pathogens. The antifungal activity of isoliquiritin against P. litchi Chen had been proven in a dose-dependent manner through in vitro (mycelial growth and sporangia germination) and in vivo (detached leaf) tests. Results revealed that isoliquiritin exhibited significant antifungal activity against the tested pathogens, especially, P. litchi Chen, with a minimum inhibitory concentration of 27.33 mg/L. The morphology of P. litchi Chen was apparently changed by isoliquiritin through cytoplasm leakage and distortion of mycelia. The cell membrane permeability of the P. litchi Chen increased with the increasing concentration of isoliquiritin, as evidenced by a rise in relative electric conductivity and a decrease in reducing sugar contents. These results indicated that the antifungal effects of isoliquiritin could be explained by a membrane lesion mechanism causing damage to the cell membrane integrity leading to the death of mycelial cells. Taken together, isoliquiritin may be used as a natural alternative to commercial fungicides or a lead compound to develop new fungicides for the c...Continue Reading

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Citations

Feb 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mengyu XingZide Jiang
Oct 22, 2016·MedChemComm·Huy X NgoKeith D Green
Feb 4, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao-Huan ZhangMing-Fang He

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