Abstract
Due to the failure of available antifungal agents in the treatment of candidemia and the toxic activities of these drugs, a lot of researches are being conducted to develop new nontoxic and effective antifungal agents for optimal control of fungal pathogens. The aim of this study is to evaluate the in vitro antifungal activity of propolis against yeasts isolated from the blood cultures of intensive care unit patients. Seventy-six strains were included in this study. The in vitro antifungal activity of propolis, fluconazole (FLU), and itraconazole (ITR) was investigated by the microdilution broth methods (CLSI guidelines M27-A3 for yeast). The propolis sample was collected from Kayseri, Turkey. Of the 76 isolates, 33 were identified as Candida albicans while 37 were C. parapsilosis, three were C. tropicalis, and three were identified as C. glabrata. The geometric mean range for MIC (μg/ml) with regard to all isolates was 0.077 to 3 μg/ml for FLU and ITR, and 0.375 to 0.70 μg/ml for propolis. It was shown that propolis had significant antifungal activity against all Candida strains and the MIC range of propolis was determined as 0185 to 3 μg/ml. This study demonstrated that propolis had significant antifungal activity against yea...Continue Reading
References
Mar 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G P Bodey
Jan 1, 1995·Antimicrobial Agents and Chemotherapy·J H RexC D Webb
Jan 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R Wingard
Nov 1, 1993·Antimicrobial Agents and Chemotherapy·M L CameronJ R Perfect
May 1, 1997·Biological & Pharmaceutical Bulletin·H MiyatakaT Satoh
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Abi-SaidS Vartivarian
Jun 20, 1998·Clinical Microbiology Reviews·T C WhiteR A Bowden
Apr 23, 1999·Diagnostic Microbiology and Infectious Disease·M A PfallerR A Hajjeh
Jan 27, 2000·Toxicology·H OrhanG Sahin
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·M A PfallerR J Hollis
Jan 5, 2002·Mycoses·C OtaM T Shimizu
Aug 3, 2004·Die Nahrung·Musa OzcanRamazan Yetişir
Apr 16, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M PopovaV Bankova
Apr 22, 2005·Mycoses·A N KocS Cankaya
Apr 26, 2005·Journal of Ethnopharmacology·Sibel Silici, Semiramis Kutluca
May 11, 2005·Microbiological Research·Ataç UzelBekir Salih
Sep 6, 2005·Journal of Pharmacological Sciences·Sibel SiliciSoner Cankaya
Dec 3, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Y OzkulE Eroğlu
Aug 17, 2006·Letters in Applied Microbiology·S Silici, A N Koc
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Nov 6, 2009·Medical Mycology·Ayşe Nedret KocHikmet Mavus-Buldu
Dec 7, 2010·Journal of Medicinal Food·Ayşe Nedret KoçBariş Derya Ercal
Citations
Feb 8, 2019·Current Pharmaceutical Biotechnology·Rawan ZeitounYolla El-Makhour
May 7, 2020·Foods·Leonardo PetruzziAntonio Bevilacqua
Jul 14, 2017·Frontiers in Pharmacology·Laura CornaraBruno Burlando
May 18, 2019·Chemistry & Biodiversity·Soukaina El-GuendouzMaria G Miguel
May 16, 2019·Scientific Reports·Mehrnoosh ZakerkishNiloofar Neisi
Apr 1, 2021·Arhiv za higijenu rada i toksikologiju·Mehmet ArslanEyyüp Rencüzoğulları
Jun 3, 2021·Biology·Nelly Rivera-YañezOscar Nieto-Yañez
Jul 3, 2021·Foods·Felix ZulhendriConrad O Perera
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena RatajczakJan Matysiak
Mar 23, 2021··Alifa Husnia AlHaqRobiatul Adawiyah