Antifungal activity of rimocidin and a new rimocidin derivative BU16 produced by Streptomyces mauvecolor BU16 and their effects on pepper anthracnose

Journal of Applied Microbiology
B J JeonBeom Seok Kim

Abstract

The objective of this study was to explore antifungal metabolites targeting fungal cell envelope and to evaluate the control efficacy against anthracnose development in pepper plants. A natural product library comprising 3000 microbial culture extracts was screened via an adenylate kinase (AK)-based cell lysis assay to detect antifungal metabolites targeting the cell envelope of plant-pathogenic fungi. The culture extract of Streptomyces mauvecolor strain BU16 displayed potent AK-releasing activity. Rimocidin and a new rimocidin derivative, BU16, were identified from the extract as active constituents. BU16 is a tetraene macrolide containing a six-membered hemiketal ring with an ethyl group side chain instead of the propyl group in rimocidin. Rimocidin and BU16 showed broad-spectrum antifungal activity against various plant-pathogenic fungi and demonstrated potent control efficacy against anthracnose development in pepper plants. Antifungal metabolites produced by S. mauvecolor strain BU16 were identified to be rimocidin and BU16. The compounds displayed potent control efficacy against pepper anthracnose. Rimocidin and BU16 would be active ingredients of disease control agents disrupting cell envelope of plant-pathogenic fungi....Continue Reading

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Citations

Aug 8, 2019·FEMS Microbiology Letters·Gislâine Vicente Dos ReisSimone Possedente de Lira
Sep 8, 2019·World Journal of Microbiology & Biotechnology·Yong YangKun-Tai Li
Mar 30, 2020·Applied Microbiology and Biotechnology·Zhangqing SongXiaoping Yu
Jan 31, 2019·Journal of Industrial Microbiology & Biotechnology·Yanfang ZhaoXiaoping Yu

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