Antifungal activity of secondary plant metabolites from potatoes (Solanum tuberosum L.): Glycoalkaloids and phenolic acids show synergistic effects

Journal of Applied Microbiology
A F Sánchez-MaldonadoM G Gänzle

Abstract

To study the antifungal effects of the potato secondary metabolites α-solanine, α-chaconine, solanidine and caffeic acid, alone or combined. Resistance to glycoalkaloids varied among the fungal species tested, as derived from minimum inhibitory concentrations assays. Synergistic antifungal activity between glycoalkaloids and phenolic compounds was found. Changes in the fluidity of fungal membranes caused by potato secondary plant metabolites were determined by calculation of the generalized polarization values. The results partially explained the synergistic effect between caffeic acid and α-chaconine and supported findings on membrane disruption mechanisms from previous studies on artificial membranes. LC/MS analysis was used to determine variability and relative amounts of sterols in the different fungal species. Results suggested that the sterol pattern of fungi is related to their resistance to potato glycoalkaloids and to their taxonomy. Fungal resistance to α-chaconine and possibly other glycoalkaloids is species dependent. α-Chaconine and caffeic acid show synergistic antifungal activity. The taxonomic classification and the sterol pattern play a role in fungal resistance to glycoalkaloids. Results improve the understand...Continue Reading

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Citations

Nov 23, 2017·Journal of Ethnobiology and Ethnomedicine·Fiona ShannonMichael Heinrich
Oct 22, 2016·MedChemComm·Huy X NgoKeith D Green
Jan 15, 2020·Preparative Biochemistry & Biotechnology·Jesús Antonio Salazar-Magallón, Arturo Huerta de la Peña
Aug 28, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Joanna MiedziankaPrzemysław Kowalczewski
Mar 29, 2020·Bioorganic & Medicinal Chemistry·Mathiu Perez RodriguezRuth E Stark
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela PacificoCarlotta Balconi
Aug 11, 2021·Plants·Jiraporn SangtaRatchadawan Cheewangkoon
Aug 29, 2021·Plants·Yusuff OladosuTaoheed Kolawole Muftaudeen

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