Antifungal activity of thiophenes from Echinops ritro

Journal of Agricultural and Food Chemistry
Nikolas FokialakisDavid E Wedge

Abstract

Extracts from 30 plants of the Greek flora were evaluated for their antifungal activity using direct bioautography assays with three Colletotrichum species. Among the bioactive extracts, the dichloromethane extract of the radix of Echinops ritro (Asteraceae) was the most potent. Bioassay-guided fractionation of this extract led to the isolation of eight thiophenes. Antifungal activities of isolated compounds together with a previously isolated thiophene from Echinops transiliensis were first evaluated by bioautography and subsequently evaluated in greater detail using a broth microdilution assay against plant pathogens Colletotrichum acutatum, Colletotrichum fragariae, Colletotrichum gloeosporioides, Botrytis cinerea, Fusarium oxysporum, Phomopsis viticola, and Phomopsis obscurans. 5'-(3-Buten-1-ynyl)-2,2'-bithiophen (1), alpha-terthienyl (2), and 2-[pent-1,3-diynyl]-5-[4-hydroxybut-1-ynyl]thiophene (5) at 3 and 30 microM were active against all three Colletotrichum species, F. oxysporum, P. viticola, and P. obscurans.

References

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Jun 12, 2003·Journal of Agricultural and Food Chemistry·Giovanni MeazzaDavid E Wedge

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Citations

Aug 1, 2010·Toxins·Stephen O DukeKevin K Schrader
Nov 22, 2011·European Journal of Medicinal Chemistry·Niina TaniRisto O Juvonen
Dec 5, 2009·Journal of Photochemistry and Photobiology. B, Biology·Guang ShaoYong-Qing Tian
Jan 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei Ping ZhaoZhi Long Liu
Nov 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Helen BitewMariamawit Yonathan Yeshak
Mar 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luciana ScottiFrancisco Jaime Bezerra Mendonça Junior
Aug 18, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing ShiHai Jiang
Apr 28, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Helena Teru TakahashiCelso Vataru Nakamura
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang-Bo LiRong-Shao Huang
Nov 19, 2019·Frontiers in Pharmacology·Helen Bitew, Ariaya Hymete
May 6, 2017·Natural Product Research·Lashyn KiyekbayevaSamir A Ross
Nov 10, 2011·Organic Letters·Hiroshi NakanoSamir A Ross
Sep 27, 2007·Journal of Agricultural and Food Chemistry·Nurhayat TabancaDavid E Wedge

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.