Antifungal agents for preventing fungal infections in non-neutropenic critically ill patients

The Cochrane Database of Systematic Reviews
Andrea CortegianiAntonino Giarratano

Abstract

Invasive fungal infections are important causes of morbidity and mortality among critically ill patients. Early institution of antifungal therapy is pivotal for mortality reduction. Starting a targeted antifungal therapy after culture positivity and fungi identification requires a long time. Therefore, alternative strategies (globally defined as 'untargeted antifungal treatments') for antifungal therapy institution in patients without proven microbiological evidence of fungal infections have been discussed by international guidelines. This review was originally published in 2006 and updated in 2016. This updated review provides additional evidence for the clinician dealing with suspicion of fungal infection in critically ill, non-neutropenic patients, taking into account recent findings in this field. To assess the effects of untargeted treatment with any antifungal drug (either systemic or nonabsorbable) compared to placebo or no antifungal or any other antifungal drug (either systemic or nonabsorbable) in non-neutropenic, critically ill adults and children. We assessed effectiveness in terms of total (all-cause) mortality and incidence of proven invasive fungal infections as primary outcomes. We searched the following databas...Continue Reading

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Citations

Jan 17, 2016·The Cochrane Database of Systematic Reviews·Andrea CortegianiAntonino Giarratano
Nov 20, 2016·Journal of Paediatrics and Child Health·Marene TerSusan Jacobs
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Dec 7, 2018·Medical Mycology Journal·Yuhko SuzukiHikaru Kume
Apr 28, 2016·Critical Care : the Official Journal of the Critical Care Forum·Andrea CortegianiAntonino Giarratano
Dec 8, 2017·BioMed Research International·Vincenzo RussottoAntonino Giarratano

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