Antifungal, antibiofilm, and antiproliferative activities of Guapira graciliflora Mart

Brazilian Oral Research
Carolina Medeiros de AlmeidaEdja Maria Melo de Brito Costa

Abstract

The aim of this study was to evaluate in vitro the antifungal, antibiofilm and antiproliferative activities of the extract from the leaves of Guapira graciliflora Mart. The phytochemical characterization of the extract was performed using electrospray ionization mass spectrometry (ESI-MS). The antimicrobial activity of the extract and its fractions was evaluated using the broth microdilution method against species of Candida. The inhibition of C. albicans biofilm was evaluated based on the number of colony-forming units (CFU) and metabolic activity (MTT). The antiproliferative activity of the extract and its fraction was evaluated in the presence of human tumor and non-tumor cells, and the cytotoxicity of the extract was determined on the RAW 264.7 macrophage line - both using the sulforhodamine B method. The phytochemical characterization indicated the presence of the flavonoids rutin and kaempferol. The extract and the methanol fraction exhibited moderate antifungal activity against C. albicans, C. krusei, and C. glabrata, and strong activity against C. dubliniensis. In the biofilms at 24 and 48 hours, the concentration of 12500 µg/mL of the extract was the most effective at reducing the number of CFU s/mL (44.4% and 42.9%, r...Continue Reading

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Citations

Apr 11, 2019·Brazilian Oral Research·Diego Romário SilvaEdja Maria Melo de Brito Costa
Aug 29, 2019·Frontiers in Microbiology·Patrícia Maria Wiziack ZagoLetícia Machado Gonçalves

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