PMID: 9544783Apr 17, 1998Paper

Antifungal antibiotic hamycin increases susceptibility of Candida albicans to phagocytosis by murine macrophages

FEMS Immunology and Medical Microbiology
J N Dhuley

Abstract

Hamycin is an antifungal antibiotic produced by Streptomyces pimprina Thirum. In the present study, the effect of hamycin on (a) the phagocytosis of Candida albicans by murine peritoneal macrophages and (b) the cell surface hydrophobicity (CSH) of C. albicans was investigated. Addition of hamycin to the culture of macrophages and Candida cells increased the susceptibility of Candida cells to the phagocytosis by macrophages. Pretreatment of Candida cells with hamycin increased their vulnerability to killing by macrophages. Examination of physico-chemical properties of Candida cell surface showed a significant decrease in the CSH. These findings suggest that the binding of hamycin to Candida cells induces biochemical/physico-chemical alterations of the surface, so that it becomes more susceptible to phagocytosis by murine macrophages.

References

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Citations

May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine A WellsRobert B Ashman
Oct 28, 1999·FEMS Immunology and Medical Microbiology·J N Dhuley
Aug 25, 1999·FEMS Immunology and Medical Microbiology·J N Dhuley

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