Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani

PLoS Neglected Tropical Diseases
Humberto E OrtegaMônica T Pupo

Abstract

Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan parasite Leishmania donovani. The bioassay guided fractionation of extracts from cultures of Streptomyces sp. ICBG292, isolated from the exoskeleton of Cyphomyrmex workers, led to the isolation of Mer-A2026B (1), piericidin-A1 (2) and nigericin (3). Nigericin (3) presented high activity against intracellular amastigotes of L. donovani (IC50 0.129 ± 0.008 μM). Streptomyces puniceus ICBG378, isolated from workers of Acromyrmex rugosus rugosus, produced dinactin (4) with potent anti-L. donovani activity against intracellular amastigotes (IC50 0.018 ± 0.003 μM). Compounds 3 and 4 showed good selectivity indexes, 88.91 and 656.11 respectively, and were more active than positive control, miltefosine. Compounds 1-4 were also active against some Escovopsis strains. Compounds 1 and 2 were also produced by Streptomyces sp. ICBG233, isolated from workers of Atta sexdens, and detected in ants' extracts by mass spectrometry, suggesting they are produced in the natural environment as defensive compounds involved in the symbiotic interaction.

References

Aug 1, 1990·The American Journal of Medicine·R E SaenzJ D Berman
Oct 10, 1968·Biochemical and Biophysical Research Communications·L K SteinraufJ W Chamberlin
Nov 1, 1981·The Journal of Antimicrobial Chemotherapy·R R NewS Heath
Apr 1, 1994·Journal of Cellular Physiology·S JiangA J Mukkada
Oct 1, 1996·The Journal of Antibiotics·A UrakawaW Yun
Feb 20, 2002·Chemical Reviews·Eric BakkerErnö Pretsch
May 31, 2002·Journal of Medicinal Chemistry·Daniel F VeberKenneth D Kopple
Jan 19, 2006·Clinical Microbiology Reviews·Simon L CroftAlan H Fairlamb
Sep 7, 2006·Journal of the American Chemical Society·Martin J SchnermannDale L Boger
Oct 17, 2007·Nature Reviews. Microbiology·François ChappuisMarleen Boelaert
Oct 27, 2007·International Journal of Food Microbiology·Wolfgang Ludwig
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ted R Schultz, Seán G Brady
Apr 22, 2008·Current Opinion in Chemical Biology·A Ganesan
Jun 25, 2008·Journal of Microbiological Methods·Orly Shimony, Charles L Jaffe
Mar 31, 2009·Nature Chemical Biology·Dong-Chan OhJon Clardy
Mar 2, 2010·Nature Chemical Biology·Johannes KroissAles Svatos
Mar 4, 2010·Genetics and Molecular Research : GMR·D González-MendozaA Alarcón
May 7, 2011·Journal of Microencapsulation·Sijumon KunjachanManish K Chourasia
Jul 27, 2012·The Journal of Antimicrobial Chemotherapy·Thomas P C DorloPeter J de Vries
May 6, 2014·Expert Opinion on Drug Discovery·Matthew Segall
Nov 5, 2015·Journal of the American Chemical Society·Ethan B Van ArnamJon Clardy
Feb 9, 2016·Journal of Natural Products·David J Newman, Gordon M Cragg
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ethan B Van ArnamJon Clardy
Jun 26, 2017·Drug Discovery Today·Bilal ZulfiqarVicky M Avery
Jul 2, 2017·Journal of Prosthodontic Research·Ahmad KutkutJamie Studts
Jul 27, 2017·Vaccine· World Health Organization
Aug 2, 2017·Vaccine· World Health Organization
Nov 29, 2017·BioMed Research International·Igor GrekovMarie Lipoldová
Feb 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Tobias EnglMartin Kaltenpoth
Mar 6, 2018·Tetrahedron Letters·Humberto E OrtegaMônica T Pupo
Aug 22, 2018·Lancet·Sakib BurzaMarleen Boelaert
Feb 2, 2019·Nature Communications·Marc G ChevretteCameron R Currie
Mar 7, 2019·Lancet·Amir Abdoli

❮ Previous
Next ❯

Citations

Aug 28, 2020·Planta medica·Carla MenegattiMônica T Pupo
Feb 5, 2021·Natural Product Research·Gui-Yun WuHai-Bo Tan
Jan 30, 2021·Environmental Microbiology·Saima Khalid, Nancy P Keller
Feb 16, 2021·Frontiers in Microbiology·Patrícia de Almeida MachadoHerbert Leonel de Matos Guedes
Oct 23, 2020·Archives of Microbiology·Munendra KumarMonisha Khanna Kapur
Jan 26, 2021·Bioorganic & Medicinal Chemistry·Humberto E OrtegaMônica T Pupo
Feb 20, 2021·PeerJ·Samar M AbdelrahmanNicole B Lopanik
Feb 25, 2021·ACS Omega·Ling-Feng ZhouYing-Lao Zhang
Mar 20, 2021·Antonie van Leeuwenhoek·Weilan Gomes da Paixão MeloFernando Carlos Pagnocca
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Jesús Chan-BacabBenjamín Otto Ortega-Morales
Jun 9, 2021·MBio·Delaney L MillerIrene L G Newton
Jul 15, 2021·Journal of Applied Microbiology·Sepideh M AzadYa-Wen He
Feb 20, 2020·Journal of Natural Products·Carla MenegattiMônica Tallarico Pupo

❮ Previous
Next ❯

Datasets Mentioned

BETA
MK118901
MK118902

Methods Mentioned

BETA
PCR
electrophoresis
PMA
NMR

Software Mentioned

SwissADME
Bruker Hystar
Stardrop
SecMan Pro DNASTAR

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.