Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Bomi HwangDong Gun Lee

Abstract

In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

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Citations

Jun 18, 2011·Biochemical and Biophysical Research Communications·Bomi HwangDong Gun Lee
Mar 19, 2014·Letters in Applied Microbiology·T KulikA Okorski
Mar 4, 2015·Biotechnology Advances·Rakshit K DevappaRobert F H Dekker
Apr 17, 2015·BMC Complementary and Alternative Medicine·Guy Sedar Singor NjatengJules-Roger Kuiate
Aug 2, 2016·Chinese Medicine·Hui-Hui XiaoMan-Sau Wong
Apr 25, 2017·Biotechnology and Bioengineering·Yongkun LvJian Chen
Feb 16, 2018·BioMed Research International·Xin LiuLongfei Yang
Oct 28, 2019·Current Topics in Medicinal Chemistry·Aurelio Ortiz, Estibaliz Sansinenea
Jun 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shiva Hemmati, Hassan Seradj
Dec 10, 2019·Journal of Plant Physiology·Elena Sánchez-ElordiM Estrella Legaz
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mebeaselassie AndargiePetr Karlovsky
Dec 21, 2019·Infectious Disorders Drug Targets·Samira KadkhodamasoumSoheila Molaei

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Methods Mentioned

BETA
column chromatography
ELISA

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