Antifungal Effects of Saponin Extract from Rhizomes of Dioscorea panthaica Prain et Burk against Candida albicans

Evidence-based Complementary and Alternative Medicine : ECAM
Longfei YangTonghui Ma

Abstract

Candida albicans is the most common fungal pathogen causing serious diseases, while there are only a paucity of antifungal drugs. Therefore, the present study was performed to investigate the antifungal effects of saponin extract from rhizomes of Dioscorea panthaica Prain et Burk (Huangshanyao Saponin extract, HSE) against C. albicans. HSE inhibits the planktonic growth and biofilm formation and development of C. albicans. 16-64 μg/mL of HSE could inhibit adhesion to polystyrene surfaces, transition from yeast to filamentous growth, and production of secreted phospholipase and could also induce endogenous reactive oxygen species (ROS) production and disrupt cell membrane in planktonic cells. Inhibitory activities against extracellular exopolysaccharide (EPS) production and ROS production in preformed biofilms could be inhibited by 64-256 μg/mL of HSE. Cytotoxicity against human Chang's liver cells is low, with a half maximal inhibitory concentration (IC50) of about 256 μg/mL. In sum, our study suggested that HSE might be used as a potential antifungal therapeutic against C. albicans.

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Citations

Jul 6, 2019·BioMed Research International·Longfei YangTonghui Ma
Jan 2, 2019·BioMed Research International·Longfei YangTonghui Ma
Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Wei LiuShengzheng Wang
Aug 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·I Irem Tatli Cankaya, E Inci Somuncuoglu
Oct 9, 2021·Chemical Biology & Drug Design·Xin LiuLongfei Yang

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Methods Mentioned

BETA
flow cytometry
confocal microscopy

Software Mentioned

GraphPad
Imaris
Expo32 ADC
GraphPad Prism

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