Abstract
Fungal infections are a major threat to public health care. Cryptococcosis in humans and animals, caused by Cryptococcus neoformans, is a life-threatening disease. In a random antifungal screening of acetone leaf extracts of 400 tree species against Cryptococcus neoformans, the following plant species had good activity: Zanthoxylum capense (Thunb.) Harv. (Rutaceae), Morusmesozygia Stapf (Moraceae), Calodendrum capense (L.f.) Thunb. (Rutaceae), Catha transvaalensis Codd (Celastraceae), Cussonia zuluensis Strey (Araliaceae), Ochna natalitia (Meisn.) Walp. (Ochnaceae), Croton sylvaticus Hochst. ex C. Krauss (Euphorbiaceae), Maytenus undata (Thunb.) Blakelock (Celastraceae), Celtis africana Burm.f. (Ulmaceae), and Cassine aethiopica Thunb. (Celastraceae). Hexane, dichloromethane, acetone, and methanol extracts of these 10 plants were tested against Cryptococcus neoformans using bioautography and microdilution assays. Acetone extracted the highest quantity of plant material. Dichloromethane and hexane extracts of Maytenus undata showed clear bands in bioautography while the other species did not produce good results in bioautography. Maytenus undata extracts had promising antifungal activity against C. neoformans, with average minim...Continue Reading
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Citations
May 22, 2013·BMC Complementary and Alternative Medicine·Tsholofelo Abednego MokokaJacobus Nicolaas Eloff
Feb 26, 2014·Journal of Ethnopharmacology·Namrita Lall, Navneet Kishore
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Fernanda P GulloAna Marisa Fusco-Almeida
Jun 26, 2017·Asian Pacific Journal of Tropical Medicine·Alfred Maroyi
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Dec 10, 2019·Journal of Ethnopharmacology·S van Vuuren, L Frank
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