Antifungal efficacy of ten selected South African plant species against Cryptococcus neoformans

Pharmaceutical Biology
T A MokokaJacobus N Eloff

Abstract

Fungal infections are a major threat to public health care. Cryptococcosis in humans and animals, caused by Cryptococcus neoformans, is a life-threatening disease. In a random antifungal screening of acetone leaf extracts of 400 tree species against Cryptococcus neoformans, the following plant species had good activity: Zanthoxylum capense (Thunb.) Harv. (Rutaceae), Morusmesozygia Stapf (Moraceae), Calodendrum capense (L.f.) Thunb. (Rutaceae), Catha transvaalensis Codd (Celastraceae), Cussonia zuluensis Strey (Araliaceae), Ochna natalitia (Meisn.) Walp. (Ochnaceae), Croton sylvaticus Hochst. ex C. Krauss (Euphorbiaceae), Maytenus undata (Thunb.) Blakelock (Celastraceae), Celtis africana Burm.f. (Ulmaceae), and Cassine aethiopica Thunb. (Celastraceae). Hexane, dichloromethane, acetone, and methanol extracts of these 10 plants were tested against Cryptococcus neoformans using bioautography and microdilution assays. Acetone extracted the highest quantity of plant material. Dichloromethane and hexane extracts of Maytenus undata showed clear bands in bioautography while the other species did not produce good results in bioautography. Maytenus undata extracts had promising antifungal activity against C. neoformans, with average minim...Continue Reading

References

May 1, 1991·Reviews of Infectious Diseases·R Saral
Jan 1, 1990·Pharmacotherapy·S F Kowalsky
Mar 1, 1990·Reviews of Infectious Diseases·J D Lazar, K D Wilner
Jun 7, 1985·Science·M F BalandrinW H Bollinger
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W G Powderly
May 3, 2000·Letters in Applied Microbiology·A NostroM A Cannatelli
Apr 3, 2001·Journal of Ethnopharmacology·L J McGawJ van Staden
Jun 10, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J N Eloff
May 17, 2005·Journal of Ethnopharmacology·P MasokoJ N Eloff

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Citations

May 22, 2013·BMC Complementary and Alternative Medicine·Tsholofelo Abednego MokokaJacobus Nicolaas Eloff
Feb 26, 2014·Journal of Ethnopharmacology·Namrita Lall, Navneet Kishore
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Fernanda P GulloAna Marisa Fusco-Almeida
Jun 26, 2017·Asian Pacific Journal of Tropical Medicine·Alfred Maroyi
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chelsea N PowersRobert L McFeeters
Dec 10, 2019·Journal of Ethnopharmacology·S van Vuuren, L Frank

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Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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