PMID: 11312903Apr 21, 2001Paper

Antifungal mechanism of polygodial

Journal of Agricultural and Food Chemistry
Isao KuboS H Lee

Abstract

The primary antifungal action of polygodial comes in part from its ability to function as a nonionic surfactant, disrupting the lipid-protein interface of integral proteins and denaturing their conformation. As a result, the antifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial, presumably caused by inhibition of the plasma membrane H(+)-ATPase. However, the potent antifungal activity of polygodial results from its multiple functions.

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Citations

Nov 5, 2013·International Journal of Biological Macromolecules·Yukun QinPengcheng Li
May 16, 2002·Journal of Applied Microbiology·K Fujita, I Kubo
May 9, 2003·Biological & Pharmaceutical Bulletin·Yutana PongpiriyadachaMasayuki Yoshikawa
Nov 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan MontenegroJoan Villena
Feb 24, 2015·Journal of Ethnopharmacology·Carmen M Leonard, Alvaro M Viljoen
Mar 18, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Keiko KuroiwaMasao Hirose
Sep 18, 2015·Organic & Biomolecular Chemistry·Jeremy JustJason A Smith
Oct 28, 2017·International Journal of Molecular Sciences·Héctor CarrascoEvelyn Silva-Moreno
Dec 24, 2005·Phytotherapy Research : PTR·Isao KuboTae Joung Ha
Nov 19, 2009·International Journal of Food Sciences and Nutrition·Yohsuke Ohtsubo
Nov 22, 2018·Frontiers in Microbiology·George DiallinasIoannis K Kostakis
Aug 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iván MontenegroMiryam Valenzuela
Mar 25, 2018·European Journal of Pharmacology·Subramanyam DasariGnanasekar Munirathinam
Jun 3, 2021·International Journal of Molecular Sciences·Purity N KipangaWalter Luyten

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