Antifungal penetration into normal rabbit nucleus pulposus

Spine
Jason M ConaughtyF J Eismont

Abstract

A rabbit model was used to assess the penetration into the nucleus pulposus of 3 commonly used antifungal medications: amphotericin B, amphotericin B lipid complex, and fluconazole. The purpose of this study was to quantitate the penetration of antifungal medications into the normal rabbit nucleus pulposus. Fungal infections of the spine are rarely, if ever, treated with medical management alone. Although antibiotic penetration into the nucleus pulposus has been studied extensively, no previous studies have attempted to quantitate the penetration of antifungals into the nucleus pulposus. Twenty-four rabbits were given 2 doses of 1 of the antifungal medications studied. One hour after completion of the second dose, the animal was killed and the thoracolumbar spine was excised en bloc. Specimens of nucleus pulposus and serum were obtained and sent to an outside laboratory for analysis. Gas chromatography was used to determine the fluconazole tissue levels, and a bioassay was used to measure amphotericin B tissue levels. Three animals in the amphotericin B group died either after the first or second dose of medication was administered. Although amphotericin B and amphotericin B lipid complex did not show adequate penetration into ...Continue Reading

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Citations

Aug 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria N GamaletsouThomas J Walsh
Aug 29, 2012·The Journal of Hospital Infection·H McDermottH Humphreys
Nov 9, 2010·Spine·Saeid KaramouzianMohammad Eskandari
Mar 31, 2015·Spine·Devin GaneshFrank Eismont
Jan 8, 2014·Clinical Microbiology Reviews·Timothy FeltonWilliam W Hope
Jun 1, 2011·Current Fungal Infection Reports·Scott W Mueller, Tyree H Kiser
Oct 31, 2020·Advanced Drug Delivery Reviews·Marianna A TryfonidouLaura B Creemers

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