Antifungal peptides: potential candidates for the treatment of fungal infections

Expert Opinion on Investigational Drugs
A J De Lucca

Abstract

Many diversely produced natural peptides, as well as those produced semisynthetically and synthetically, have been found to inhibit the growth or even be lethal to a wide range of fungi. Some of these have the potential to aid mankind in combating mycoses caused by emerging pathogens or as a result of the increasing number of antibiotic-resistant fungi. Antifungal peptides may also assist in non-medical fields such as agriculture. For example, introduction by transgenic research of antifungal peptides could improve crop production yields by increasing host resistance to fungal invasion. The aim of this review is to provide information on research on these important peptides.

References

Dec 1, 1976·Archives of Biochemistry and Biophysics·B J BaumR W Longton
Sep 1, 1992·Antimicrobial Agents and Chemotherapy·T ChapmanJ Houston
Sep 1, 1992·Cornea·I R SchwabC J Murphy
Aug 31, 1992·Biochemical and Biophysical Research Communications·J R BorgmeyerQ K Huynh
Jan 15, 1992·Biochemical and Biophysical Research Communications·Q K HuynhJ F Zobel
Sep 1, 1991·Mycopathologia·S GottliebE Segal
Dec 1, 1991·Journal of Dairy Science·M TomitaK Kawase
Nov 1, 1991·Cellular Immunology·J F Gera, A K Lichtenstein
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·L H HansonD A Stevens
Sep 1, 1991·The Journal of Antibiotics·K TakesakoH Yamaguchi
Jan 25, 1991·Cell·R I LehrerM E Selsted
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G DiamondC L Bevins
Dec 1, 1990·Oral Microbiology and Immunology·E C BrantJ J Pollock
Jun 15, 1990·Experientia·V Arondel, J C Kader
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D SchmatzM J Turner
Sep 1, 1990·The Journal of Antibiotics·T IwamotoM Okuhara
Apr 1, 1990·Antimicrobial Agents and Chemotherapy·R F HectorD Pappagianis
Jan 1, 1990·European Journal of Haematology·T GanzR I Lehrer
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B ChristensenD Mauzerall
Jun 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M A PfallerR Wenzel
Jul 1, 1989·Infection and Immunity·P B EisenhauerR I Lehrer
Oct 1, 1989·International Journal of Peptide and Protein Research·R M Kini, H J Evans
Aug 1, 1989·The Journal of Clinical Investigation·R I LehrerM E Selsted
Sep 11, 1989·FEBS Letters·A SegreJ Takemoto
May 1, 1989·Antimicrobial Agents and Chemotherapy·K A McIntyre, J N Galgiani
Dec 1, 1988·Antimicrobial Agents and Chemotherapy·C S TaftC P Selitrennikoff
Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
Jan 1, 1988·Annals of the New York Academy of Sciences·R S GordeeM Debono
Feb 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E D SpitzerG S Kobayashi
Jan 1, 1987·Annual Review of Microbiology·H G Boman, D Hultmark
Aug 29, 1988·FEBS Letters·H C ChenC M Huang
Jun 1, 1986·Infection and Immunity·R I LehrerM E Selsted
Aug 1, 1986·Journal of General Microbiology·P MonetonF Le Goffic
Jan 1, 1987·The Journal of Antibiotics·C RossiL Radics
Jul 1, 1985·Infection and Immunity·M E SelstedR I Lehrer
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·P J McCarthyW D Kingsbury
Apr 25, 1986·Biochimica Et Biophysica Acta·C LatoudJ L Morgat
May 1, 1985·The Journal of Infectious Diseases·G P SegalM E Selsted
Oct 1, 1985·The Journal of Clinical Investigation·M E SelstedR I Lehrer
Mar 1, 1973·The Journal of Antibiotics·T AraiK Yazawa
Dec 17, 1969·Journal of the American Chemical Society·K IsonoS Suzuki
Jun 1, 1983·Antimicrobial Agents and Chemotherapy·J M BeckerF Naider
Sep 1, 1984·The Journal of Antibiotics·R S GordeeL C Howard
Aug 1, 1983·The Journal of Antibiotics·Y MoriT Arai
Nov 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·M DigelW Voelter
Nov 1, 1981·Reviews of Infectious Diseases·J J Bullen
Aug 1, 1995·Antimicrobial Agents and Chemotherapy·M B KurtzD Armstrong
Feb 28, 1994·Toxicology·B L KaganR I Lehrer
Aug 15, 1995·FEMS Microbiology Letters·F C AdetuyiJ Takemoto
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·D SchmatzJ Andersen
Apr 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·S I MyersA Castaneda
May 1, 1995·Molecular Plant-microbe Interactions : MPMI·K M KraghJ D Mikkelsen
Apr 4, 1995·Biochemistry·E M TytlerJ P Segrest
May 1, 1995·The Plant Cell·FRG. TerrasJ. Vanderleyden
Jan 1, 1994·Annual Review of Microbiology·M Debono, R S Gordee
Jan 1, 1995·The Journal of Applied Bacteriology·S E BlondelleR A Houghten
Jul 1, 1994·The Journal of Applied Bacteriology·M LebbadiE Valdivia
Oct 1, 1994·The Journal of Antibiotics·T IwamotoM Kohsaka
Jul 1, 1994·European Journal of Biochemistry·M MorenoF García-Olmedo
Dec 1, 1993·Antimicrobial Agents and Chemotherapy·M S AlcouloumreJ E Edwards
Apr 11, 1994·FEBS Letters·S S HarwigR I Lehrer
Sep 1, 1993·The Journal of Antibiotics·K TakesakoH Yamaguchi
Dec 27, 1993·Gene·E Sun, F E Cohen
Jan 21, 1994·Journal of Medicinal Chemistry·F A BouffardD McFadden
Jan 1, 1993·Annual Review of Immunology·R I LehrerT Ganz
Aug 1, 1995·Current Opinion in Structural Biology·S H WhiteM E Selsted
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P FehlbaumJ A Hoffmann
Nov 1, 1995·Trends in Biochemical Sciences·Y Shai
Feb 19, 1996·FEBS Letters·I VouldoukisA Mor
Mar 1, 1996·Fungal Genetics and Biology : FG & B·V N Tariq, P L Devlin
May 1, 1996·European Journal of Biochemistry·A AumelasA Chavanieu
Jun 21, 1996·The Journal of Biological Chemistry·K. ThevissenW F Broekaert
May 1, 1996·Antimicrobial Agents and Chemotherapy·J V Martinez-Suarez, J L Rodriguez-Tudela
Feb 1, 1996·Trends in Biotechnology·S E Blondelle, R A Houghten
Aug 5, 1996·Biochemical and Biophysical Research Communications·K RamalingamM J Levine
Jan 1, 1996·The Journal of Membrane Biology·A M FeiginJ G Brand
Feb 1, 1996·Antimicrobial Agents and Chemotherapy·N H Georgopapadakou, T J Walsh
Jan 1, 1997·Plant Physiology·K K NielsenJ D Mikkelsen
Feb 1, 1997·Antimicrobial Agents and Chemotherapy·A J DeLuccaT J Walsh
Nov 1, 1996·Diagnostic Microbiology and Infectious Disease·M E ErnstM A Pfaller
Feb 1, 1997·Natural Product Reports·D C GournelisR Verpoorte
Mar 1, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M B Kurtz, C M Douglas
Aug 1, 1997·Antimicrobial Agents and Chemotherapy·M Del PoetaJ R Perfect
Sep 23, 1997·Protein Science : a Publication of the Protein Society·C LandonM Ptak
Sep 26, 1997·Antimicrobial Agents and Chemotherapy·K V Clemons, D A Stevens
Nov 21, 1997·Biochimica Et Biophysica Acta·H Tsai, L A Bobek
Nov 26, 1997·Antimicrobial Agents and Chemotherapy·K BartizalJ Balkovec
Nov 26, 1997·Antimicrobial Agents and Chemotherapy·R HajduH Kropp
Dec 12, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M MeisterJ A Hoffmann
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LemaitreJ A Hoffmann
Feb 10, 1998·Biochemistry·S U PatelJ M Thornton
Mar 6, 1998·Molecular Plant-microbe Interactions : MPMI·L CavallarinB San Segundo
Jun 20, 1998·Clinical Microbiology Reviews·T C WhiteR A Bowden
May 29, 1998·Infection and Immunity·Y ChoR I Lehrer
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·M A PowlesD Schmatz
Oct 10, 1998·The Journal of Antibiotics·K N SorensenJ Takemoto
Oct 22, 1998·Advances in Experimental Medicine and Biology·H WakabayashiH Yamaguchi
Oct 31, 1998·Antimicrobial Agents and Chemotherapy·R K PettitK C Hazen
Nov 11, 1998·FEMS Microbiology Letters·R Wangspa, J Takemoto
Jan 13, 1999·Molecular Plant-microbe Interactions : MPMI·A SeguraF García-Olmedo
Jan 29, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D BrewerG Lajoie
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·A J De LuccaT J Walsh
Mar 6, 1999·The Journal of Biological Chemistry·E J HelmerhorstT Abee
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·L J GreenW L Current
May 20, 1999·Biopolymers·F García-OlmedoP Rodríguez-Palenzuéla
May 29, 1999·Antimicrobial Agents and Chemotherapy·R K Li, M G Rinaldi
Jun 26, 1999·The Journal of Biological Chemistry·S E KoshlukovaM Edgerton
Jun 29, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F BarchiesiM G Rinaldi
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·S Y HongK H Lee
Mar 1, 1995·Trends in Cell Biology·M E Selsted, A J Ouellette
Apr 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·M LANDY, G H WARREN
Jan 1, 1996·Bioscience, Biotechnology, and Biochemistry·S OitaS O Yanagi

Citations

Jun 1, 2006·Mycotoxin Research·K RajasekaranT E Cleveland
Mar 24, 2000·Plant Science : an International Journal of Experimental Plant Biology·J W CaryT E Cleveland
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Bryskier
Nov 10, 2001·Annual Review of Phytopathology·S E GoldA D Martínez-Espinoza
Jun 13, 2012·Immunopharmacology and Immunotoxicology·Preethi Sheshadri, Jayanthi Abraham
Sep 11, 2007·Toxicon : Official Journal of the International Society on Toxinology·A B Becker-RittC R Carlini
Nov 5, 2002·Trends in Pharmacological Sciences·Jacopo Vizioli, Michel Salzet
Aug 10, 2016·Future Medicinal Chemistry·Tecla CiociolaLuciano Polonelli
Jan 26, 2017·Frontiers in Microbiology·Beatriz T MeneguettiOctávio L Franco
Oct 30, 2004·The Journal of Biological Chemistry·M MangoniLuis Rivas
Aug 10, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kate E PettitAaron B Caughey
Jul 25, 2018·Frontiers in Microbiology·Tomoko OhshimaNobuko Maeda
Apr 8, 2020·Frontiers in Cellular and Infection Microbiology·Miguel Fernández de UllivarriPaul D Cotter
Jan 16, 2020·International Journal of Environmental Research and Public Health·Sharon PeloEzekiel Green

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Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

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