Antifungal Properties of Crude Extracts, Fractions, and Purified Compounds from Bark of Curatella americana L. (Dilleniaceae) against Candida Species

Evidence-based Complementary and Alternative Medicine : ECAM
Cleyton Eduardo Mendes de ToledoTânia Ueda-Nakamura

Abstract

The ethnomedicinal plant Curatella americana L. (Dilleniaceae) is a common shrub in the Brazilian cerrado, in which crude extract showed antifungal activity in a preliminary study. In this work, the antifungal and cytotoxic properties of the crude extract, fractions, and isolated compounds from C. americana were evaluated against the standard yeast strains Candida albicans, C. tropicalis, and C. parapsilosis, clinical isolates, and fluconazole-resistant strains. The combinatory effects between subfractions and isolated compounds and effects on cell morphology, virulence factors, and exogenous ergosterol were also evaluated. The MIC obtained against the Candida species including fluconazole-resistant strain ranged from 15.3 to 31.3 µg/mL for crude extract, 3.9 to 15.6 µg/mL for ethyl acetate fraction, and 7.8 to 31.3 µg/mL for subfractions. The isolated compounds identified as 4'-O-methyl-catechin, epicatechin-3-O-gallate, and 4'-O-methyl-catechin-3-O-gallate showed lower antifungal activity than the crude extract and fractions (MIC ranging from 31.3 to 125.0 µg/mL). The addition of exogenous ergosterol to yeast culture did not interfere in the antifungal activity of the extract and its fractions. Synergistic antifungal activity...Continue Reading

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Citations

May 31, 2018·Antimicrobial Agents and Chemotherapy·Cristina de Castro SpadariKelly Ishida
Oct 31, 2017·Frontiers in Microbiology·Diana L Zuza-AlvesGuilherme M Chaves
Jun 23, 2021·Journal of Ethnopharmacology·Natthavadh Laokor, Weerapong Juntachai

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Datasets Mentioned

BETA
HTO2234

Methods Mentioned

BETA
nuclear magnetic resonance
enzyme-linked
Fluorescence
column chromatography

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