Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus

Journal of Fungi
Sevtap Arikan-AkdagliJacques F Meis

Abstract

Antifungal resistance is a topic of concern, particularly for specific fungal species and drugs. Among these are the multidrug-resistant Candida auris and azole-resistant Aspergillus fumigatus. While the knowledge on molecular mechanisms of resistance is now accumulating, further data are also available for the clinical implications and the extent of correlation of in vitro resistance to clinical outcomes. This review article summarizes the epidemiology of C. auris infections, animal models focusing on the activity of novel antifungal compounds in C. auris infections, virulence factors, and the mechanisms of antifungal resistance for this multi-resistant Candida species. Regarding A. fumigatus, the significance of azoles in the treatment of A. fumigatus infections, reference methods available for the detection of resistance in vitro, molecular mechanisms of secondary azole resistance, routes of acquisition, and clinical implications of in vitro resistance are covered to provide guidance for the current status of azole resistance in A. fumigatus.

References

Jun 1, 1997·Antimicrobial Agents and Chemotherapy·D W DenningS L Kelly
Apr 21, 2009·Applied and Environmental Microbiology·Eveline SneldersPaul E Verweij
Sep 2, 2010·Antimicrobial Agents and Chemotherapy·Klaus Leth MortensenMaiken Cavling Arendrup
Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Oct 18, 2011·Emerging Infectious Diseases·Jan W M van der LindenPaul E Verweij
Nov 16, 2011·Future Microbiology·David W Denning, David S Perlin
Sep 21, 2013·Emerging Infectious Diseases·Anuradha ChowdharyJacques F Meis
Jun 26, 2014·Emerging Infectious Diseases·Rindidzani E MagoboNelesh P Govender
Dec 17, 2014·Intensive Care Medicine·Arunaloke ChakrabartiDeepak Mendiratta
May 20, 2015·Emerging Infectious Diseases·J W M van der LindenP E Verweij
May 20, 2015·Emerging Infectious Diseases·Maha EmaraRitu Bafna
Jun 7, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Gülşah Ece ÖzmerdivenHalis Akalın
Aug 19, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Paul E VerweijJ Peter Donnelly
Sep 9, 2015·BMC Genomics·Sharanya ChatterjeeUtpal S Tatu
Oct 22, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul E VerweijJacques F Meis
Nov 10, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Anupam PrakashAnuradha Chowdhary
Jan 27, 2016·Mycoses·Sarah Santos GonçalvesArnaldo Lopes Colombo
Jul 2, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas F PattersonJohn E Bennett
Jul 28, 2016·The Journal of Infection·Belinda CalvoArnaldo Lopes Colombo
Sep 17, 2016·The Journal of Hospital Infection·A ChowdharyJ F Meis
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
Oct 30, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MeletiadisM C Arendrup
Nov 25, 2016·Journal of Clinical Microbiology·Masako MizusawaSean X Zhang
Dec 17, 2016·Emerging Infectious Diseases·Soraya E Morales-LópezJosé Y Rodríguez
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shawn R LockhartAnastasia P Litvintseva
Dec 19, 2016·International Journal of Antimicrobial Agents·Philipp KoehlerMaria J G T Vehreschild
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Jan 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jacques F MeisPaul E Verweij
Jan 19, 2017·Emerging Infectious Diseases·Ronen Ben-AmiTalya Finn
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Shivaprakash M RudramurthyAnup Ghosh
Apr 6, 2017·Mycoses·Hyoung Il ChoiJun Seong Son
Apr 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sang Taek HeoDimitrios P Kontoyiannis
May 10, 2017·Antimicrobial Agents and Chemotherapy·Elizabeth L BerkowShawn R Lockhart
May 26, 2017·Journal of Clinical Microbiology·Milena KordalewskaDavid S Perlin

❮ Previous
Next ❯

Citations

Dec 27, 2018·Mycoses·Mahdi AbastabarHamid Badali
Jul 25, 2019·Journal of Fungi·Daniel Z P Friedman, Ilan S Schwartz
Oct 28, 2019·Journal of Fungi·Amal Al MaaniAbdullah M S Al-Hatmi
Jan 16, 2020·Journal of Fungi·Mireille H van der TorreRiina Rautemaa-Richardson
Jan 8, 2020·Pharmaceutics·Célia Faustino, Lídia Pinheiro
Jun 20, 2019·Molecular Biology Reports·Shahram MahmoudiSadegh Khodavaisy
Oct 3, 2019·Journal of Fungi·Erik H VogelzangKarin van Dijk
Jul 24, 2020·Current Fungal Infection Reports·Alison R NovakScott W Mueller
Nov 9, 2019·Journal of Fungi·Mariagrazia Di LucaAndrej Trampuz
Nov 8, 2020·Bioorganic & Medicinal Chemistry Letters·James M ApgarMichael Peel

❮ Previous
Next ❯

Methods Mentioned

BETA
Whole Genome Sequencing

Software Mentioned

EUCAST

Related Concepts

Related Feeds

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Related Papers

Methods in Molecular Biology
Brunella PosteraroMaurizio Sanguinetti
The New England Journal of Medicine
Adilia WarrisPaul E Verweij
The Journal of Antimicrobial Chemotherapy
Ahmed BueidDavid W Denning
© 2022 Meta ULC. All rights reserved