Abstract
Antifungal resistance and several putative virulence factors have been associated with the pathogenicity of the Candida parapsilosis species complex. The objective of this study was to evaluate the antifungal susceptibility, the production of virulence factors and the pathogenicity of the C. parapsilosis complex. Overall, 49 isolates of C. parapsilosis sensu stricto, 19 C. orthopsilosis and nine C. metapsilosis were used. The planktonic and biofilm susceptibility to fluconazole, itraconazole, voriconazole, amphotericin B and caspofungin was assessed using a broth microdilution assay. Finally, the production of biofilm and hydrolytic enzymes and the fungal pathogenicity against Caenorhabditis elegans were investigated.Results/Key findings. Overall, one C. orthopsilosis was resistant to caspofungin and susceptible-dose-dependent to itraconazole, the other two C. orthopsilosis were susceptible-dose-dependent to fluconazole and itraconazole, and one C. metapsilosis was susceptible-dose-dependent to azoles. A total of 67.5 % of the isolates were biofilm producers. Amphotericin B and caspofungin caused the greatest reduction in the metabolic activity and biomass of mature biofilms. Phospholipase and protease production was observed i...Continue Reading
References
Jul 28, 2001·Journal of Clinical Microbiology·G LuoJ Y Yau
Jan 18, 2002·Infection and Immunity·D M KuhnM A Ghannoum
Jan 7, 2005·Journal of Clinical Microbiology·Arianna TavantiFrank C Odds
Oct 16, 2008·Clinical Microbiology Reviews·David TrofaJoshua D Nosanchuk
Aug 19, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S S GonçalvesA L Colombo
Oct 14, 2009·Critical Reviews in Microbiology·Eveline C van AsbeckDavid A Stevens
Nov 26, 2009·International Journal of Medical Microbiology : IJMM·Ali Abdul LattifMahmoud A Ghannoum
Jul 20, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M de ToroJ Aznar
Jul 28, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio NucciArnaldo L Colombo
Aug 28, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Matthew E FalagasKonstantinos Z Vardakas
Jan 19, 2011·FEMS Microbiology Ecology·Raimunda S N BrilhanteMarcos F G Rocha
Sep 21, 2011·Antimicrobial Agents and Chemotherapy·Emilia CantónUNKNOWN FUNGEMYCA Study Group
Aug 30, 2012·Medical Mycology·Rogelio de J Treviño-RangelGloria M González
Feb 14, 2013·Mycopathologia·Luciana da Silva RuizClaudete Rodrigues Paula
Jul 23, 2013·PloS One·Tibor NémethAttila Gácser
Oct 10, 2013·FEMS Yeast Research·Érika A Abi-ChacraAndré L S Santos
Nov 7, 2013·Virulence·Sara GagoAna Alastruey-Izquierdo
Dec 4, 2013·Eukaryotic Cell·Srisuda PannanusornUte Römling
Jan 1, 2015·Medical Mycology·Rossana de Aguiar CordeiroMarcos Fábio Gadelha Rocha
Jul 4, 2015·Mycopathologia·Beatriz Virgínia da SilvaAnderson Assunção Andrade
Jul 23, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Ralciane de Paula MenezesReginaldo Dos Santos Pedroso
Aug 28, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Fábio Silvestre AtaidesMaria do Rosário Rodrigues Silva
Sep 1, 2015·International Journal of Medical Microbiology : IJMM·Mariangela ZiccardiAndré L S Santos
Aug 11, 2016·BMC Infectious Diseases·Francesco BarchiesiEsther Manso
Aug 17, 2016·Current Protein & Peptide Science·Renata TothAttila Gacser
Aug 17, 2016·Veterinary Microbiology·Raimunda Sâmia Nogueira BrilhanteMarcos Fábio Gadelha Rocha
May 2, 2017·Revista iberoamericana de micología·Xiomara MorenoMaribel Dolande
Sep 6, 2017·Journal of Biomedical Science·Sourour NejiAli Ayadi
Nov 28, 2017·Veterinary Microbiology·Rossana de Aguiar CordeiroMarcos Fábio Gadelha Rocha
Citations
Mar 1, 2019·Journal of Clinical Microbiology·Iva KotáskováTomáš Freiberger
Aug 17, 2019·Frontiers in Cellular and Infection Microbiology·Amir ArastehfarTeun Boekhout
Jun 4, 2019·Biofouling·Raimunda Sâmia Nogueira BrilhanteDébora de Souza Collares Maia Castelo-Branco
Mar 19, 2020·Current Pharmaceutical Design·Laura Caminitti de LimaTaís Maria Bauab
Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Priscila Guerino Vilela AlvesDenise Von Dolinger de Brito Röder
May 9, 2019·Biofouling·Marcos Fábio Gadelha RochaRaimunda Sâmia Nogueira Brilhante
Dec 22, 2019·Journal of Fungi·Gustavo FontechaSharleen Braham
Jul 29, 2020·Frontiers in Microbiology·Yinggai SongRuoyu Li
Jul 3, 2021·Journal of Fungi·Marina ZoppoArianna Tavanti