Antifungal susceptibility and virulence of Candida parapsilosis species complex: an overview of their pathogenic potential

Journal of Medical Microbiology
Raimunda Sâmia Nogueira BrilhanteMarcos Fábio Gadelha Rocha

Abstract

Antifungal resistance and several putative virulence factors have been associated with the pathogenicity of the Candida parapsilosis species complex. The objective of this study was to evaluate the antifungal susceptibility, the production of virulence factors and the pathogenicity of the C. parapsilosis complex. Overall, 49 isolates of C. parapsilosis sensu stricto, 19 C. orthopsilosis and nine C. metapsilosis were used. The planktonic and biofilm susceptibility to fluconazole, itraconazole, voriconazole, amphotericin B and caspofungin was assessed using a broth microdilution assay. Finally, the production of biofilm and hydrolytic enzymes and the fungal pathogenicity against Caenorhabditis elegans were investigated.Results/Key findings. Overall, one C. orthopsilosis was resistant to caspofungin and susceptible-dose-dependent to itraconazole, the other two C. orthopsilosis were susceptible-dose-dependent to fluconazole and itraconazole, and one C. metapsilosis was susceptible-dose-dependent to azoles. A total of 67.5 % of the isolates were biofilm producers. Amphotericin B and caspofungin caused the greatest reduction in the metabolic activity and biomass of mature biofilms. Phospholipase and protease production was observed i...Continue Reading

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Citations

Mar 1, 2019·Journal of Clinical Microbiology·Iva KotáskováTomáš Freiberger
Jun 4, 2019·Biofouling·Raimunda Sâmia Nogueira BrilhanteDébora de Souza Collares Maia Castelo-Branco
Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Priscila Guerino Vilela AlvesDenise Von Dolinger de Brito Röder
May 9, 2019·Biofouling·Marcos Fábio Gadelha RochaRaimunda Sâmia Nogueira Brilhante
Dec 22, 2019·Journal of Fungi·Gustavo FontechaSharleen Braham

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