Antifungal Susceptibility of Emerging Dimorphic Pathogens in the Family Ajellomycetaceae

Antimicrobial Agents and Chemotherapy
Karolina DukikJacques F Meis

Abstract

The in vitro susceptibilities of 24 molecularly identified dimorphic fungi belonging to the genera Adiaspiromyces, Blastomyces, and Emergomyces within the family Ajellomycetaceae were tested against 8 standard antifungal agents using CLSI document M38-A2. Amphotericin B and posaconazole had the lowest geometric mean MICs (<0.05 μg/ml) followed by itraconazole (<0.07 μg/ml), voriconazole (<0.15 μg/ml), and isavuconazole (<0.42 μg/ml) while fluconazole was not active. Micafungin demonstrated good in vitro antifungal activity against Emergomyces (geometric mean minimum effective concentration [GM MEC] 0.1 μg/ml) and Blastomyces (GM MEC <0.017 μg/ml).

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Citations

Mar 15, 2018·Medical Mycology·Abdullah M S Al-HatmiG Sybren de Hoog
Sep 6, 2018·Revista de salud pública·Adelaida Gaviria-RiveraLuz E Cano-Restrepo
Jul 25, 2019·Journal of Fungi·Daniel Z P Friedman, Ilan S Schwartz
Jan 4, 2020·Journal of Clinical Microbiology·Tsidiso G MaphangaNelesh P Govender
Oct 30, 2019·Mycopathologia·Malini R CapoorArunaloke Chakrabarti
Aug 24, 2019·Emerging Infectious Diseases·Isabelle RoomsVolker Rickerts
Mar 20, 2018·Emerging Infectious Diseases·Ilan S SchwartzLynne Sigler
Feb 1, 2020·Mycopathologia·Vishnu Chaturvedi, G Sybren de Hoog

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