Abstract
We have evaluated the efficacy of posaconazole (PSC), voriconazole (VRC), and amphotericin B (AMB) in a murine model of systemic infection by Cryptococcus gattii using immunocompromised animals and three clinical strains of the fungus. AMB was the most effective drug in prolonging the survival of mice and also in reducing tissue burden in all organs tested. To a lesser degree, VRC at 60 mg/kg of body weight in lung tissue and PSC at 40 mg/kg also in spleen demonstrated good efficacy in reducing the fungal load. The PSC and VRC levels in serum and brain tissue, determined by an agar diffusion bioassay method at 4 h after the last dose of the therapy, were above the corresponding MIC values. However, these drugs were not able to reduce the fungal load in brain tissue. Our results demonstrated that PSC and, to a lesser degree, VRC, have fungistatic activity and potential for the treatment of human pulmonary cryptococcosis.
References
Aug 1, 1985·Journal of Clinical Microbiology·C A BodetD J Drutz
Nov 1, 1985·The Journal of Infectious Diseases·K J ChristiansenD Armstrong
Dec 1, 1993·Infection and Immunity·J O Hill, P L Dunn
Aug 1, 1996·Antimicrobial Agents and Chemotherapy·J R PerfectW A Schell
Jan 20, 2000·Infection and Immunity·K L Buchanan, H A Doyle
Mar 24, 2000·Diagnostic Microbiology and Infectious Disease·Y C ChenW C Hsieh
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M S SaagW E Dismukes
Feb 13, 2001·Antimicrobial Agents and Chemotherapy·A M Sugar, X P Liu
May 11, 2001·Medical Mycology·T C Sorrell
Nov 8, 2001·AIDS·G FrieseJ Lohmeyer
Dec 6, 2001·The Journal of Antimicrobial Chemotherapy·F BarchiesiG Scalise
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectElizabeth Johnson
Sep 1, 2004·The Journal of Infection·N BodasingD Kennedy
Dec 14, 2004·Blood·M E Christine LutsiakHelen Sabzevari
Aug 10, 2005·The Journal of Infectious Diseases·Anastasia P LitvintsevaThomas G Mitchell
Sep 2, 2005·The Journal of Antimicrobial Chemotherapy·Punnee PitisuttithumCatherine J Hardalo
Jun 30, 2006·Medical Mycology·William C UickerKent L Buchanan
May 8, 2007·The Journal of Antimicrobial Chemotherapy·Carolina SerenaJosep Guarro
May 20, 2008·Revista Do Instituto De Medicina Tropical De São Paulo·Andrea de Siqueira Campos LindenbergBodo Wanke
Jun 19, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Gomez-LopezM Cuenca-Estrella
Oct 29, 2008·Antimicrobial Agents and Chemotherapy·George R ThompsonThomas F Patterson
Jan 31, 2009·Medical Mycology·Koichi IzumikawaShigeru Kohno
Feb 12, 2009·Mycoses·András FittlerLajos Botz
Jan 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectTania C Sorrell
Citations
Feb 15, 2012·Antimicrobial Agents and Chemotherapy·Fabiola Fernández-SilvaJosep Guarro
Jul 25, 2013·Mycoses·Fabiola Fernández-SilvaJosep Guarro
Sep 7, 2016·Medical Mycology Case Reports·Stefanie DesmetBert Bammens
Jun 27, 2018·Expert Opinion on Drug Metabolism & Toxicology·Katharine E Stott, William Hope
Jan 8, 2014·Clinical Microbiology Reviews·Timothy FeltonWilliam W Hope
Dec 14, 2019·Archives of Microbiology·Cristina de Castro SpadariKelly Ishida
Dec 1, 2010·Eukaryotic Cell·Yaoping Liu, Scott G Filler
Oct 17, 2019·Journal of Fungi·Elizabeth Dodds Ashley
Oct 11, 2017·Medical Mycology·Marliete Carvalho CostaDaniel Assis Santos
Apr 24, 2020·Drugs·Lu ChenRoger J M Brüggemann