Antifungal treatment strategies in high risk patients

Mycoses
Maria J G T RüpingOliver A Cornely

Abstract

We discuss different strategies for the treatment of invasive fungal infections (IFI) in high risk patients with a focus on patients experiencing profound and prolonged neutropenia, comprising those with acute myelogenous leukaemia (AML) or myelodysplastic syndrome (MDS) during remission induction chemotherapy and on patients undergoing allogeneic haematopoietic stem cell transplantation (SCT). Among these patients, invasive aspergillosis (IA) is the most frequently observed form of IFI, as opposed to high risk intensive care unit (ICU) patients in whom an increased incidence of invasive candidiasis (IC) can be observed. In both groups, initiation of early treatment has a profound impact on mortality rates, but adequate diagnostic tools are lacking. These circumstances have led to the parallel use of different treatment strategies, e.g. prophylaxis, empiric, pre-emptive and targeted treatment of IFI. The optimum treatment strategies for these severe infections are a matter of extensive research and discussion. A review of major clinical trials on the issue reveals that comparisons between different treatment strategies cannot be made. Considering the complexity of the issue, we advocate an eclectic treatment approach that reduc...Continue Reading

References

Oct 1, 1989·Archives of Internal Medicine·S B WeyR P Wenzel
Oct 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P MartinoA Cassone
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Abi-SaidS Vartivarian
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S KaoR A Hajjeh
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M BlumbergUNKNOWN National Epidemiology of Mycoses Survey(NEMIS) Study Group
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Jan 25, 2002·The New England Journal of Medicine·Thomas J WalshUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Dec 20, 2002·The New England Journal of Medicine·Jorge Mora-DuarteUNKNOWN Caspofungin Invasive Candidiasis Study Group
Mar 11, 2003·Critical Care Medicine·Hervé DupontJean-Marie Desmonts
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN NIAID Mycoses Study Group
Nov 1, 2003·The Lancet Infectious Diseases·Philippe EggimannDidier Pittet
Sep 11, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Daniel J Diekema, Michael A Pfaller
Sep 17, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L Ostrosky-Zeichner
Oct 27, 2004·Emerging Infectious Diseases·Alison MorrisJonathan E Kaplan
Apr 9, 2005·Journal of Clinical Microbiology·Benito AlmiranteUNKNOWN Barcelona Candidemia Project Study Group
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard P Wenzel, Chris Gennings
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Reginald E GreeneRobert H Rubin
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Jan 26, 2007·The New England Journal of Medicine·Andrew J UllmannSimon Durrant
Jan 26, 2007·The New England Journal of Medicine·Oliver A CornelyDavid Angulo-Gonzalez
Mar 3, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L Ostrosky-ZeichnerJ H Rex
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oliver A CornelyUNKNOWN AmBiLoad Trial Study Group
May 8, 2007·Lancet·Ernst-Rüdiger KuseUNKNOWN Micafungin Invasive Candidiasis Working Group
Jun 15, 2007·The New England Journal of Medicine·Annette C ReboliUNKNOWN Anidulafungin Study Group
Jul 31, 2007·Future Microbiology·Jordi Vila, Robert A Bonomo

❮ Previous
Next ❯

Citations

May 26, 2009·Revista iberoamericana de micología·Juan Carlos Pozo-Laderas
Sep 11, 2009·Current Opinion in Infectious Diseases·David S Perlin
Oct 5, 2011·Antimicrobial Agents and Chemotherapy·Valeria AllizondAnna Maria Cuffini
Apr 2, 2011·The Lancet Infectious Diseases·Hsin-Yun Sun, Nina Singh
Mar 1, 2011·Diagnostic Microbiology and Infectious Disease·Silvia AranciaDaniela Fortini
Jul 13, 2013·Mycoses·Pankaj MalhotraArunaloke Chakrabarti
May 6, 2015·Colloids and Surfaces. B, Biointerfaces·Katarzyna NiemirowiczHalina Car
May 23, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Arnaldo Lopes ColomboMarcio Nucci
Jun 30, 2016·Expert Review of Anti-infective Therapy·Kathleen M JobCatherine M T Sherwin
Jul 29, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Katarzyna NiemirowiczRobert Bucki
Sep 12, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jessica E MorganRobert S Phillips
Jan 8, 2019·Chemistry & Biodiversity·Marissa Robles-MartínezRosalba Patiño-Herrera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.