Antigastric autoantibodies and gastric secretory function in Helicobacter pylori-infected patients with duodenal ulcer and non-ulcer dyspepsia

Scandinavian Journal of Gastroenterology
G FallerT Kirchner

Abstract

Autoantibodies against epitopes located at the canaliculi of human parietal cells occur in about 30% of Helicobacter pylori-infected patients. This has led to the hypothesis that gastric secretory function could be inhibited by anticanalicular autoantibodies in H. pylori gastritis. Forty-four H. pylori-infected patients with and without duodenal ulcers were screened for anticanalicular autoantibodies by means of immunohistochemistry. Plasma gastrin levels and basal and maximal gastric acid output were determined. Fasting gastrin levels were significantly increased in the group with anticanalicular autoantibodies. In the group of patients with non-ulcer dyspepsia the presence of anticanalicular autoantibodies was significantly correlated with an impaired basal acid secretion. Antigastric autoimmunity in H. pylori gastritis seems to be relevant for gastric hyposecretion either directly by inhibiting the proton pump or indirectly through the development of gastric mucosa atrophy.

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Citations

Mar 20, 2001·Infection and Immunity·T O CróinínB Drumm
Dec 15, 2004·Microbes and Infection·Mario Milco D'EliosGianfranco Del Prete
Mar 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K SugiuK Haruma
Jan 30, 2002·The Journal of Pediatrics·Gerhard FallerThomas Kirchner
Dec 8, 2004·Virchows Archiv : an International Journal of Pathology·Gerhard Faller, Thomas Kirchner
Apr 6, 2001·International Journal of Clinical & Laboratory Research·D BassoM Plebani
Mar 15, 2005·International Reviews of Immunology·Mathijs P BergmanGianfranco Del Prete
Sep 28, 2002·European Journal of Gastroenterology & Hepatology·Uta KiltzRomuald J Adamek
May 1, 2002·European Journal of Gastroenterology & Hepatology·Masanori ItoKazuaki Chayama
Sep 16, 2000·Acta medica Austriaca·G Oberhuber, A Haidenthaler
Mar 5, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yan ZhangHermann Brenner

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