PMID: 6159446Nov 1, 1980Paper

Antigen- and receptor-driven regulatory mechanisms. V. The failure of idiotype-coupled spleen cells to induce unresponsiveness in animals lacking the appropriate VH genes is caused by the lack of idiotype-matched targets

The Journal of Experimental Medicine
M S SyM I Greene

Abstract

A/J anti-p-azobenzenearsonate (ABA) antibodies bearing cross-reactive idiotypic (CRI) determinants, when coupled to spleen cells and then injected intravenously into naive animals, stimulate suppressor T cell (Ts) responses. Moreover, previous studies have demonstrated that the ability of such idiotype-coupled spleen cells to induce immune unresponsiveness to subsequent immunization with ABA-coupled spleen cells is linked to Igh-1 genes. Thus, CRI bearing antibodies from A/J mice, when conjugated to normal BALB/c spleen cells in vitro and then injected intravenously to syngeneic BALB/c mice, failed to induce tolerance in these animals. However, spleen cells taken from these animals transferred significant degrees of suppression to Igh-1 congenic C.AL-20 but not to H-2 congenic, Igh-1 distinct B10.D2 mice. Therefore, the failure of CRI-coupled spleen cells to induce suppressor cell- mediated unresponsiveness in animals unable to express the appropriate VH genes (i.e. BALB/c and B10.D2) appears to be caused by the lack of idiotype- matched targets. The notion that the ability to express certain Vn genes in the recipient animal is a prerequisite for suppressor cell function was further supported by the observation that suppressor ...Continue Reading

References

Oct 1, 1979·The Journal of Experimental Medicine·Y Dohi, A Nisonoff

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Citations

Aug 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
Nov 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
Feb 1, 1983·The Journal of Experimental Medicine·S S Chen, D H Katz
Jan 21, 2014·Biochimica Et Biophysica Acta·Brett BurkholderRuo-Pan Huang
Dec 1, 1990·Cellular Immunology·Y MorikawaK Saito
Jan 1, 1982·European Journal of Immunology·F L OwenP D Gottlieb

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