PMID: 6165799Feb 1, 1981Paper

Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells

The Journal of Experimental Medicine
M H DietzR N Germain

Abstract

Azobenzenearsonate (ABA)-specific T cell-derived suppressor factor (TsF1) from A/J mice was used to induced second-order suppressor T cells (Ts2). Comparison of suppressor T cells induced by antigen (Ts1) with Ts2 induced by TsF1 revealed that Ts1 were afferent suppressors active only when given at the time of antigen priming, and not thereafter, whereas Ts2 could act when transferred at any time up to 1 d before antigen challenge for a delayed-type hypersensitivity response. This was true even when the recipient could be shown to be fully immune before transfer of Ts2, thus defining these cells as efferent suppressors. The anti-idiotypic specificity of the Ts2 was demonstrated by the ability of Ts to bind to idiotype (cross-reactive idiotype [CRI])-coated Petri dishes. A soluble extract from Ts2 (TsF2) was also capable of mediating efferent suppression that was functionally antigen- (ABA) specific. Comparison of TsF1 with this new factor, TsF2, revealed that both lack Ig-constant-region determinants, possess H-2-coded determinants, and show specific binding (to ABA and to CRI+-Ig, respectively). TsF1 acts in strains that differ with respect to H-2 and background genes, whereas TsF2 shows H-2- and non-H-2-linked genetic restric...Continue Reading

References

Dec 1, 1978·The Journal of Immunology : Official Journal of the American Association of Immunologists·L L PerryM I Greene
Nov 1, 1977·The Journal of Experimental Medicine·M Taniguchi, J F Miller
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May 1, 1980·Springer Seminars in Immunopathology·R N Germain, B Benacerraf

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Citations

May 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·A S AptM M Averbakh
Dec 18, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Varuna R AluvihareAlexander G Betz
Jan 1, 1983·Pharmacology & Therapeutics·W E Magee, S S Ristow
Jan 1, 1982·Veterinary Immunology and Immunopathology·R B BankertY H Jou
Apr 13, 2000·Veterinary Immunology and Immunopathology·I J Kim, J M Sharma
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R B WhitakerB Benacerraf
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K T HayGlassM S Sy
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M M Abu-HadidG L Mayers
Nov 1, 1982·The Journal of Experimental Medicine·M TakaokiM I Greene
Aug 1, 1988·International Reviews of Immunology·M E DorfR M O'Hara
Jan 1, 1982·Annals of the New York Academy of Sciences·B BenacerrafM E Dorf
Jan 1, 1983·Annals of the New York Academy of Sciences·C J Bellone, S Jayaraman
Nov 1, 1981·Immunology Today·B Rubin, M Pierres
Dec 1, 1990·Cellular Immunology·Y MorikawaK Saito
Mar 1, 1986·Infection and Immunity·R L MosleyR A Cox

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