Antigen avoidance tests for diagnosis of chronic hypersensitivity pneumonitis

Respiratory Investigation
Toshiharu TsutsuiNaohiko Inase

Abstract

Chronic hypersensitivity pneumonitis (HP) is induced by the inhalation of specific antigens. Patients with chronic HP may be able to improve their prognosis by avoiding these antigens. Chronic HP is often difficult to distinguish from idiopathic interstitial pneumonias (IIPs). This study was performed to find out how antigen avoidance tests contribute to the diagnosis of chronic HP. A retrospective analysis was conducted on 265 patients who underwent 2-week antigen avoidance tests between April 2002 and March 2012. The patients were classified into the following categories: acute HP, chronic HP, collagen vascular disease-associated interstitial pneumonia (CVD-IP), lung dominant connective tissue disease (LD-CTD), and IIPs. The following seven clinical parameters were evaluated: vital capacity, alveolar-arterial oxygen pressure difference, Krebs von den Lungen-6, surfactant protein-D, white blood cell count, C-reactive protein, and body temperature. These parameters were compared between the chronic HP group and a control group consisting of CVD-IP, LD-CTD, and IIPs. One-hundred and ninety-six patients with chronic HP and 43 control subjects were evaluated. All clinical parameters improved significantly in the chronic HP group b...Continue Reading

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Citations

Oct 11, 2016·Radiologic Clinics of North America·Andrea L MageeJonathan H Chung
Jul 15, 2020·Expert Review of Respiratory Medicine·Amit ChopraMarc A Judson
Aug 9, 2020·Nature Reviews. Disease Primers·Ulrich CostabelMoises Selman
Jul 27, 2021·Frontiers in Medicine·Marc A Judson

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