Antigen-Directed Fabrication of a Multifunctional Nanovaccine with Ultrahigh Antigen Loading Efficiency for Tumor Photothermal-Immunotherapy

Advanced Materials
Jinbin PanXiu-Ping Yan

Abstract

Current antigen-encapsulated multifunctional nanovaccines for oncotherapy suffer from limited antigen loading efficiency, low yield, tedious manufacture, and systemic toxicity. Here, an antigen-directed strategy for the fabrication of multifunctional nanovaccine with ultrahigh antigen loading efficiency in a facile way for tumor photothermal-immunotherapy is shown. As a proof of concept, a model antigen ovalbumin (OVA) is used as a natural carrier to load a representative theranostic agent indocyanine green (ICG). Mixing OVA and ICG in aqueous solution gives the simplest multifunctional nanovaccine so far. The nanovaccine owns antigen loading efficiency of 80.8%, high yield of >90%, intense near-infrared absorption and fluorescence, excellent reproducibility, good aqueous solubility and stability, and favorable biocompatibility. These merits not only guarantee sensitive labeling/tracking and efficient stimulation of dendritic cells, but also reliable imaging-guided photothermal-immunotherapy of tumors and tumor prevention. The proposed strategy provides a facile and robust method for large-scale and reproducible fabrication of multifunctional nanovaccines with ultrahigh antigen loading efficiency for tumor therapy.

References

Feb 25, 2006·Nature Reviews. Cancer·Pier-Luigi LolliniGuido Forni
Jan 7, 2009·Journal of the American Chemical Society·Jianping XieJackie Y Ying
Mar 17, 2010·Seminars in Immunology·Taylor H SchreiberEckhard R Podack
May 6, 2010·Journal of the American Chemical Society·Nan MaJianghong Rao
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
Mar 23, 2012·Nature Reviews. Cancer·Matthew Vanneman, Glenn Dranoff
Mar 23, 2012·Nature Reviews. Cancer·Karolina Palucka, Jacques Banchereau
Mar 23, 2012·Nature Reviews. Immunology·Nicholas P RestifoSteven A Rosenberg
Jul 31, 2013·Immunity·Jasper G van den Boorn, Gunther Hartmann
Sep 21, 2013·Nature·Corbin E Meacham, Sean J Morrison
Jan 25, 2014·Nature Reviews. Cancer·Pierre G CoulieThierry Boon
Jul 18, 2014·Nanoscale·D JaqueJ García Solé
Aug 16, 2014·Advanced Materials·Peng HuangXiaoyuan Chen
Dec 4, 2014·ACS Nano·Kun ShaoPere Santamaria
Dec 17, 2014·Nature Biotechnology·Sirkka B StephanMatthias T Stephan
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 5, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Xiu-feng ZhangYa-lin Tang
Jun 25, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Cai ZhangShao-Kai Sun
Jul 15, 2015·Chemical Reviews·Darrell J IrvineTalar Tokatlian
Apr 26, 2016·Advanced Materials·Qian Chen, Zhuang Liu
Aug 27, 2016·Biomaterials·Qiwen ChenShiguo Sun
Mar 10, 2017·ACS Nano·Guizhi ZhuXiaoyuan Chen
Mar 25, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Min LuoJinming Gao
Apr 25, 2017·Nature Nanotechnology·Min LuoJinming Gao
Jun 27, 2017·ACS Applied Materials & Interfaces·Wenguo ZhaoWeiping Gao
Jan 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weitao YangBingbo Zhang

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Citations

Jul 28, 2018·Advanced Healthcare Materials·Xiaodong ZengXuechuan Hong
Jun 6, 2019·Chemical Society Reviews·Wei SangXiaoyuan Chen
Mar 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shiyu WanYuji Pu
Apr 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaomin SuoDandan Liu
May 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ying ZhouMaolin Pang
Aug 14, 2020·Advanced Healthcare Materials·Shuren WangYanglong Hou
Feb 9, 2019·Frontiers in Immunology·Soultan Al-HalifaDenis Archambault
Apr 17, 2020·Angewandte Chemie·Shuangqian YanXiaogang Liu
Oct 1, 2020·Biomaterials Science·Tongyi ShangBin Yang
Feb 6, 2020·Angewandte Chemie·Shuang LiuHuiyu Liu
Jul 17, 2020·Angewandte Chemie·Jingchao LiKanyi Pu
Feb 5, 2021·ACS Biomaterials Science & Engineering·Pei-Yao XuAi-Zheng Chen
Feb 13, 2021·Small·Fatemeh OroojalianMohammad-Ali Shahbazi
Dec 9, 2020·Advanced Materials·Mengyu ChangJun Lin
Mar 23, 2021·ACS Applied Materials & Interfaces·Guiqiang ZhangMing Hu
Mar 29, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Deepak S ChauhanMurali M Yallapu
Apr 23, 2021·Macromolecular Bioscience·Liwen FuChuanglong He
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
May 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bin LiuKai Liu
Apr 12, 2019·Chemical Reviews·Bowen YangJianlin Shi
Dec 26, 2018·ACS Applied Materials & Interfaces·Hui ZhangXue-Bo Yin

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