Mar 1, 1980

Antigen expression by somatic cell hybrids of a murine embryonal carcinoma cell with thymocytes and L cells

Somatic Cell Genetics
P W Andrews, P N Goodfellow

Abstract

Thymocyte x PCC4azaR (a murine embryonal carcinoma cell) hybrid cells resembled PCC4azaR. They continued to express two embryonic antigens (SSEA-1 and 3C4-10) found on PCC4azaR, but did not express the thymocyte antigens Thy-1 and Ly-2. However, H-2Kk of thymocyte origin continued to be expressed, while H-2Db of PCC4azaR origin was not reexpressed. This is consistent with H-2 expression being subject to cis control. In syngeneic hosts these hybrids formed tumors containing stem cells and differentiated derivatives. In contrast, an L-cell x PCC4azaR hybrid resembled the L-cell parent, did not express SSEA-1 and 3C4-10, but did express both H-2Kk and H-2Db. In syngeneic hosts this hybrid formed undifferentiated sarcomas.

  • References25
  • Citations40

References

Mentioned in this Paper

Sarcoma
T-Lymphocyte
Neoplasms
Embryonal Carcinoma
Mice, Inbred C3H
L Cells (Cell Line)
Mice, Nude
Mature Teratoma
H-2 Antigens
Hybrid Cells

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