PMID: 8940321Dec 4, 1996Paper

Antigen-independent determinants of cadaveric kidney transplant failure

JAMA : the Journal of the American Medical Association
G M ChertowB M Brenner

Abstract

To determine the association of various antigen-independent factors with long-term cadaveric kidney transplant failure. Cohort analytic study. Kidney transplant centers (N=131) in the United States. A total of 31 515 patients who received cadaveric kidney transplants between October 1987 and December 1991. Patients with unknown or uninterpretable vital status or graft survival time (n=264 [0.8%]) were excluded. Graft failure, estimated at 2 extremes, depending on whether the death of a patient with a functioning graft was censored ("censored graft failure") or not ("uncensored graft failure"). During the 62-month study period, 5883 patients required the reinstitution of dialysis because of graft failure, 2404 patients died with graft failure, and 2041 patients died with a functioning graft. The relative risks of censored and uncensored graft failure were significantly associated with donor age, sex, and race and recipient body surface area, after adjusting for recipient age, sex, race, diabetes, cold ischemia time, panel cross-reactivity, pretransplant blood transfusions, previous renal transplantation, functional status, and HLA antigen mismatch. In cadaveric kidney transplantation, selected demographic and anthropometric fact...Continue Reading

Citations

Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N IchikawaN Murase
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