Antigen-induced bronchial anaphylaxis in actively sensitized guinea-pigs: effect of long-term treatment with sodium cromoglycate and aminophylline

British Journal of Pharmacology
P Andersson, H Bergstrand


1 The effects of long-term treatment with sodium cromoglycate (SCG) and aminophylline on antigen-induced bronchoconstriction have been studied in guinea-pigs actively sensitized according to two different regimens (one producing IgE- and IgG-like antibodies and the other producing exclusively IgG-like antibodies). 2 Treatment for three weeks with SCG (10 mg/kg) and aminophylline (10, 30 or 60 mg/kg) led to a decreased bronchial response capacity which persisted even three days after treatment ceased. In this respect SCG was effective only in guinea-pigs sensitized to produce at least partly IgE-like antibodies; aminophylline was effective in guinea-pigs sensitized to produce both IgE and/or IgG antibodies. 3 The results in vivo with SCG were reflected in vitro by a reduced capacity of chopped lung tissue to release histamine at antigen challenge; lungs from animals treated with aminophylline did not show reduced histamine releasing capacity. 4 Acute treatment with atropine was shown to reduce significantly the antigen-induced bronchial contraction in guinea-pigs sensitized to produce both IgE- and IgG-antibodies. No effect of atropine was seen on an IgG-mediated anaphylaxis. 5 Increased reactivity to methacholine but not to his...Continue Reading


Jan 1, 1977·International Archives of Allergy and Applied Immunology·S S Mahajani, R D Kulkarni
Jan 1, 1978·International Archives of Allergy and Applied Immunology·H G JohnsonJ B Wright
Jan 7, 1977·European Journal of Pharmacology·L TrinerM Verosky
Dec 1, 1975·The Journal of Allergy and Clinical Immunology·D H BryantL Lazarus
Aug 30, 1968·Science·L M Lichtenstein, S Margolis
Dec 8, 1973·British Medical Journal·D H BryantL Lazarus
Sep 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·R J PerperA L Oronsky
Jun 1, 1967·British Journal of Pharmacology and Chemotherapy·H O Collier, G W James
Oct 1, 1972·The Journal of Allergy and Clinical Immunology·I L BernsteinM Yamate
Apr 1, 1969·British Journal of Diseases of the Chest·M C Kennedy
Dec 1, 1970·Acta Allergologica·B Elgefors, H Formgren
Jan 3, 1981·Lancet·M G HarriesT S Orr
Apr 1, 1981·Agents and Actions·I Moodley, J L Mongar
Feb 1, 1958·The American Journal of Physiology·M O AMDUR, J MEAD


Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Nov 1, 1989·Agents and Actions·G W CarnathanR G Van Inwegen
Aug 1, 1989·Agents and Actions·J C NolanJ M Yanni
Jan 7, 1992·European Journal of Pharmacology·S L UnderwoodD Raeburn
Apr 28, 1993·European Journal of Pharmacology·N NakagawaH Aishita
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J W Burnett, G J Calton
Jan 1, 1986·International Journal of Immunopharmacology·L Garcez Do CarmoB B Vargaftig
Oct 1, 1991·The Journal of Pharmacy and Pharmacology·R G Van AmsterdamJ Zaagsma
Jul 9, 2004·Respiratory Physiology & Neurobiology·Nathalie SchützWalid Habre
Nov 1, 1987·British Journal of Pharmacology·J RandonB B Vargaftig
Sep 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I Erjefält, C G Persson
Apr 1, 1985·British Journal of Pharmacology·A DetsouliB B Vargaftig

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