PMID: 9159213Feb 15, 1997Paper

Antigen-induced death of T-lymphocytes

Frontiers in Bioscience : a Journal and Virtual Library
D Kabelitz, O Janssen

Abstract

Resting mature T-lymphocytes are activated when they are triggered via their antigen-specific T-cell receptor (TCR) molecule or the associated CD3 antigen. In contrast, preactivated T-cells can undergo activation-induced cell death (AICD) in response to the same signals. Stimulation of activated T-cells upregulates the expression of the Fas-ligand, and the interaction of Fas-ligand with the corresponding Fas receptor triggers an apoptosis program that culminates in cellular suicide usually associated with the fragmentation of DNA into oligonucleosomal bands. Molecular evidence indicates that proteases related to interleukin-1-beta converting enzyme play an essential role in the execution of cell death. AICD of mature T-lymphocytes can be efficiently triggered by monoclonal antibodies against the CD3/TCR complex, or by superantigens such as bacterial enterotoxins. Although it is more difficult to induce AICD by conventional peptide antigens, it is now clear that antigen-induced AICD is a powerful means of eliminating antigen-reactive T-cells. Therefore, AICD contributes to the regulation (i.e., termination) of cellular immune responses. In addition, AICD might play a role in the establishment of peripheral immune tolerance. Incr...Continue Reading

Citations

May 16, 1998·Transplantation·D Kabelitz
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian ZhangAlison Finnegan
Jun 20, 2019·Frontiers in Pharmacology·Abraam M Yakoub, Stefan Schülke
Apr 25, 2002·Molecular and Cellular Biology·Randy ShenGen-Sheng Feng
May 11, 2005·Immunological Reviews·Hui-Chen HsuJohn D Mountz
Oct 25, 2013·Expert Opinion on Investigational Drugs·Andreas Lutterotti, Roland Martin
Jan 21, 2018·Cell Death & Disease·Michael A SecinaroRalph C Budd
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ZhangT T Glant
Nov 24, 2007·European Journal of Immunology·Denise PargmannTarik Möröy
Nov 19, 2011·Immunotherapy·Hugo Mendieta-Zerón
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May 23, 2001·Free Radical Biology & Medicine·M A PahlavaniA Richardson
Jun 3, 2008·Journal of Autoimmunity·Ruth EtzenspergerLars Fugger

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