PMID: 6182177Nov 1, 1982

Antigen-induced neutrophil chemotactic activity from sensitized lung

The Journal of Allergy and Clinical Immunology
E SchenkelB Zweiman


We have used the model of ovalbumin-sensitized guinea pigs to define the source of antigen-derived, high-molecular-weight neutrophil chemotactic activity (NCA). Incubating sensitized lung fragments with specific antigen (ovalbumin) but not irrelevant antigen (bovine serum albumin) or buffer resulted in the release of high-molecular-weight NCA and histamine, suggesting a lung mast cell origin for NCA. High-molecular-weight NCA accounted for greater than 90% of the NCA observed after antigen-lung incubation. The importance of high-molecular-weight NCA in recruitment of neutrophilic leukocytes to the site of allergic inflammatory reactions is emphasized.


Oct 1, 1979·The Journal of Allergy and Clinical Immunology·P C AtkinsF Rosenblum
Mar 1, 1971·The Journal of Experimental Medicine·A B KayK F Austen
Oct 2, 1980·The New England Journal of Medicine·E J Goetzl
Sep 1, 1980·The Journal of Allergy and Clinical Immunology·G L MartinB Zweiman


Nov 1, 1987·The Journal of Allergy and Clinical Immunology·P H HowarthS T Holgate
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Jul 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J Doherty, D L Easty
Jan 1, 1988·Pediatric Pulmonology·S A Blythe, R F Lemanske
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