PMID: 6182177Nov 1, 1982

Antigen-induced neutrophil chemotactic activity from sensitized lung

The Journal of Allergy and Clinical Immunology
E SchenkelB Zweiman

Abstract

We have used the model of ovalbumin-sensitized guinea pigs to define the source of antigen-derived, high-molecular-weight neutrophil chemotactic activity (NCA). Incubating sensitized lung fragments with specific antigen (ovalbumin) but not irrelevant antigen (bovine serum albumin) or buffer resulted in the release of high-molecular-weight NCA and histamine, suggesting a lung mast cell origin for NCA. High-molecular-weight NCA accounted for greater than 90% of the NCA observed after antigen-lung incubation. The importance of high-molecular-weight NCA in recruitment of neutrophilic leukocytes to the site of allergic inflammatory reactions is emphasized.

References

Oct 1, 1979·The Journal of Allergy and Clinical Immunology·P C AtkinsF Rosenblum
Mar 1, 1971·The Journal of Experimental Medicine·A B KayK F Austen
Oct 2, 1980·The New England Journal of Medicine·E J Goetzl
Sep 1, 1980·The Journal of Allergy and Clinical Immunology·G L MartinB Zweiman

Citations

Nov 1, 1987·The Journal of Allergy and Clinical Immunology·P H HowarthS T Holgate
Dec 24, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lucie RousselSimon Rousseau
Jul 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J Doherty, D L Easty
Jan 1, 1988·Pediatric Pulmonology·S A Blythe, R F Lemanske
Mar 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucie RousselSimon Rousseau

Related Concepts

Antigens
Cell Motility
Macrophage Chemotactic Factors
Chemotactic Factors, Eosinophil
Molecular Sieve Chromatography
Cavia porcellus
Histamine Release
Lung
Neutrophil Band Cells
Ovalbumin

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