PMID: 2110603Jan 1, 1990Paper

Antigen-induced T-cell changes: modulation by pharmacologic agents

Lung
J VargheseM Schuyler

Abstract

To determine the effect of pharmacologic modulation of alterations of peripheral blood T-cell subsets caused by antigen-induced bronchoconstriction, we administered albuterol immediately after antigen-induced bronchoconstriction in a double-blind to protocol to 12 atopic asthmatic subjects. We also administered cromolyn sodium before antigen to 7 of the same subjects. Peripheral blood T-cell subset composition (CD4, CD8, Ia) of a highly purified T-cell preparation was determined before, 24, 48, 72, and 168 h after bronchoconstriction. We found that placebo inhalation immediately after antigen-induced bronchoconstriction did not affect subsequent peripheral blood T-cell subset changes (decrease in CD4+ and increase in Ia+ T lymphocytes). In contrast, inhaled albuterol abolished these T-cell subset changes. Although cromolyn sodium significantly decreased the severity of antigen-induced bronchoconstriction, it did not affect T-cell subset composition changes at the dosage used. We conclude that albuterol can ablate T-cell subset changes associated with antigen-induced bronchoconstriction. Cromolyn sodium ameliorates bronchoconstriction, but has no affect on T-cell subset composition changes. This implies that T-cell changes and b...Continue Reading

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Citations

Apr 2, 2008·The Pediatric Infectious Disease Journal·Bandaru AnuradhaVijaya Lakshmi Valluri
Mar 1, 1991·The American Review of Respiratory Disease·A A GerblichM R Schuyler
Sep 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anthony JoethamErwin W Gelfand
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony JoethamErwin W Gelfand

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