PMID: 9537061Jan 1, 1980Paper

Antigen-initiated B-lymphocyte differentiation. XVII. The inhibitory effects of recent antigen prepriming on the subsequent responsiveness of 'pre-progenitor' B cells

Scandinavian Journal of Immunology
M HowardK Shortman

Abstract

We have analysed the transient unresponsiveness of B cells following specific antigen prepriming. The effect is restricted to adoptive-transfer antibody-forming cell (AFC) progenitors (that is, 'pre-progenitors') and does not occur with the separate subset of cell culture AFC progenitors ('direct progenitors'). The transient unresponsiveness is displayed by both primary and secondary 'pre-progenitor' B cells. Mixing experiments and experiments with athymic mice indicate that the effect is not due to suppressor T cells or other inhibitory cells. Nor is the effect due to an impaired seeding ability of the activated or antigen-binding cells, since after adoptive transfer the preprimed cells can be activated by an appropriate non-specific stimulus. The most likely explanation involves direct interaction of specific antigen with the antigen receptors on 'pre-progenitor' B cells, rendering these cells more prone to temporary or permanent 'tolerance' on further antigen contact or, alternatively, directing their differentiation away from IgM AFC production on day 8 after transfer.

References

Jan 1, 1979·Immunological Reviews·G J NossalF L Battye
Nov 1, 1975·Journal of Immunological Methods·B L Pike
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C BruynsJ Urbain

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