PMID: 8609395Apr 15, 1996Paper

Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals

The Journal of Immunology : Official Journal of the American Association of Immunologists
G LombardiR Lechler

Abstract

Conflicting results of the effects of Ag presentation by MHC class II-expressing T cells have been described. In some studies class II-expressing T cells have been shown to act as effective APCs, while others have reported that the recognition of Ag on the surface of another T cell inactivates IL-2 production. In this study we have investigated the mechanisms involved in Ag presentation by T cells. The results obtained suggest that 1) lack of costimulation is not responsible for the inhibitory effects of T cell Ag presentation on IL-2 production; the provision of costimulation by immobilized anti-CD28 Ab or by the addition of accessory cells failed to reverse the effects of T cell Ag presentation, but restored the response to immobilized anti-CD3; 2) T cell Ag presentation induced a minimal increase in intracellular Ca2+ compared with that induced by antigen-pulsed B cells; this difference in the calcium response is not explained by quantitative differences in ligand density between B cells and T cells; and 3) despite the weak calcium signal, T cell presentation supported IL-4 release in the absence of IL-2 production. Taken together these data suggest that T cell Ag presentation leads to altered TCR/CD3-transduced signals, whi...Continue Reading

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
R G HargreavesG Lombardi
The Journal of Immunology : Official Journal of the American Association of Immunologists
C DubeyS L Swain
Annals of the New York Academy of Sciences
K B UrdahlS D Norton
© 2021 Meta ULC. All rights reserved