PMID: 6974758Oct 1, 1981Paper

Antigen presentation to human T lymphocytes. I. Different requirements for stimulation by hapten-modified cells vs. cell sonicates

The Journal of Experimental Medicine
S L AbramsonR R Rich

Abstract

We have investigated the cellular and antigenic requirements for incubation of secondary proliferative responses by human T lymphocytes. Two distinct properties of antigen-presenting peripheral blood mononuclear cells were studied: (a) the ability for appropriate cell surface constituents to construct an immunogenic moiety, and (b) the ability to present similar antigenic determinants when they are not covalently bound. Only Ia+ hapten-modified cells were effective stimulators. In contrast, both Ia+ and Ia- cell sonicates could stimulate secondary proliferative responses, but only in the presence of an accessory cell. This accessory cell was present in Ia+ macrophage, but not in Ia+ non-T lymphocyte, preparations. In contrast, macrophages or soluble factors produced by macrophages were not required for primed T cells to undergo hapten-specific proliferation in response to hapten-modified Ia+ stimulator cells. Thus, although all Ia+ cells tested can stimulate primed cells to proliferate, not all Ia+ cells can function as accessory cells for responses to sonicates. This may reflect the unique ability of a subpopulation(s) of Ia+ cells to bind or process sonicates or soluble antigens for appropriate recognition by primed T cells.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R S GehaE J Yunis
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R M Steinman, M D Witmer
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·W E PaulA S Rosenthal
Oct 1, 1979·The Journal of Clinical Investigation·M F SeldinS L Abramson
Feb 1, 1974·The Journal of Experimental Medicine·R M Steinman, Z A Cohn
May 1, 1980·The Journal of Experimental Medicine·M C Nussenzweig, R M Steinman
Jan 1, 1981·European Journal of Immunology·E C LattimeO Stutman
Dec 1, 1980·The Journal of Experimental Medicine·G H SunshineM Feldmann

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Citations

Dec 1, 1986·Human Immunology·T L GerrardA S Fauci

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