Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways

Current Opinion in Immunology
Fabiola OsorioSophie Janssens

Abstract

The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become clear that the functions of the UPR stretch far beyond their canonical role and intersect with seemingly unrelated functions such as innate immunity and antigen presentation. The aim of the present review is to dissect how the UPR interferes directly and indirectly with the major processes of MHC-I and MHC-II antigen presentation.

Citations

Mar 18, 2020·Cells·Giusy Di Conza, Ping-Chih Ho
Aug 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Murali GanesanNatalia A Osna
Aug 14, 2020·Journal of Cell Science·Hery UrraClaudio Hetz
Nov 20, 2018·Frontiers in Immunology·Paulina García-GonzálezFabiola Osorio
Mar 10, 2021·Trends in Cell Biology·Eelco van AnkenRoberto Sitia
Sep 8, 2019·Trends in Parasitology·Anaïs F PoncetSabrina Marion
Mar 1, 2020·The American Journal of Pathology·Scott A Oakes

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